The microphysics of surrogates of exhaled aerosols from the upper respiratory tract
The microphysics of surrogates of exhaled aerosols from the upper respiratory tract
复制标题
上呼吸道呼出气溶胶替代物的微物理学
DOI：
10.1080/02786826.2023.2299214
复制
发表时间：
2024
影响因子：
5.2
通讯作者：
Tian J
中科院分区：
文献类型：
--
作者：
Tian J
空气传播在COVID-19等呼吸道疾病的传播中发挥着重要作用，呼吸道气溶胶飞沫负责潜在传染性病原体的传播。然而，在呼出过程中的气溶胶的物理化学动力学还没有很好地理解。目前用于实验室研究的呼出气溶胶和悬浮液介质的呼吸液滴替代物的代表性仍有争议。本文用比较动力学电动天平比较了氯化钠、人工唾液（AS）和Dulbecco改良Eagle培养基（DMEM）三种替代呼吸气溶胶液滴的蒸发动力学和平衡热力学。气溶胶的吸湿响应和相行为的液滴组成的潜在影响，以及粘蛋白的影响。平衡吸湿性测量被用来验证和基准的预测复杂的解决方案，使用单气溶胶颗粒干燥动力学和轨迹模型的蒸发动力学。我们表明，成分复杂的培养基，不同于氯化钠和人工唾液（无粘蛋白的解决方案）。当在一定湿度范围内干燥时，DMEM蒸发动力学包含三个不同的阶段，包括在环境湿度范围内蒸发时的半溶解阶段。比较了低相对湿度下粘蛋白对AS和DMEM液滴蒸发和相行为的影响。在这两种情况下，粘蛋白延迟的液滴的结晶时间，但它促进相变（从均匀的半溶解/球形夹杂物）发生在较高的水活性。
Airborne transmission plays a significant role in the transmission of respiratory diseases such as COVID-19, for which the respiratory aerosol droplets are responsible for the transportation of potentially infectious pathogens. However, the aerosol physicochemical dynamics during the exhalation process are not well understood. The representativeness of respiratory droplet surrogates of exhaled aerosol and suspension media for aerosols currently used for laboratory studies remains debated. Here, we compare the evaporation kinetics and equilibrium thermodynamics of surrogate respiratory aerosol droplets including sodium chloride, artificial saliva (AS) and Dulbecco’s modified Eagle’s medium (DMEM) by using the Comparative Kinetics Electrodynamic Balance. The potential influences of droplet composition on aerosol hygroscopic response and phase behavior, and the influence of mucin are reported. The equilibrium hygroscopicity measurement was used to verify and benchmark the prediction of evaporation kinetics of complex solutions using the Single Aerosol Particle Drying Kinetics and Trajectory model. We show that the compositionally complex culture media which differs from sodium chloride and artificial saliva (mucin-free solutions). The DMEM evaporation dynamics contained three distinctive phases when drying at a range of humidities, including a semi-dissolved phase when evaporating at the environmental humidity range. The effect of mucin on droplet evaporation and phase behavior at low RH were compared between AS and DMEM solutions. In both cases, mucin delayed the crystallization time of the droplets, but it promoted phase change (from homogenous to semi-dissolved/spherical with inclusions) to occur at higher water activities.
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DOI：
10.1073/pnas.2109750119
发表时间：
2022-01-25
影响因子：
11.1
作者：
Huynh E;Olinger A;Woolley D;Kohli RK;Choczynski JM;Davies JF;Lin K;Marr LC;Davis RD
通讯作者：
Davis RD
DOI：
10.1126/science.abd9149
发表时间：
2021-08-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Wang CC;Prather KA;Sznitman J;Jimenez JL;Lakdawala SS;Tufekci Z;Marr LC
通讯作者：
Marr LC
影响因子：
5.2
作者：
Haddrell, Allen;Rovelli, Grazia;Reid, Jonathan
通讯作者：
Reid, Jonathan
影响因子：
18.2
作者：
Walker JS;Archer J;Gregson FKA;Michel SES;Bzdek BR;Reid JP
通讯作者：
Reid JP
影响因子：
6.4
作者：
Schuit, Michael;Ratnesar-Shumate, Shanna;Dabisch, Paul
通讯作者：
Dabisch, Paul