Type 1 innate lymphoid cells: Soldiers at the front line of immunity.
Type 1 innate lymphoid cells: Soldiers at the front line of immunity.
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DOI：
10.1016/j.bj.2020.10.001
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发表时间：
2021-04
影响因子：
5.5
通讯作者：
Shibuya A
中科院分区：
文献类型：
--
作者：
Nabekura T;Shibuya A
先天性淋巴样细胞（inate lymphoid cells，ILC）是存在于组织中的先天性淋巴细胞，具有保护宿主免受病原体侵害的功能，并调节组织炎症和稳态。ILC亚群响应于局部环境中的感染、炎症和组织损伤而快速产生特定的细胞因子。1型ILC（ILC1）迅速且大量地产生干扰素（IFN）-γ，但缺乏明显的细胞毒活性。ILC1与自然杀伤（NK）细胞具有许多表型、发育和功能特征，后者是具有强效天然细胞毒性的循环先天淋巴细胞。然而，最近的研究已经确定ILC1与NK细胞不同。ILC1主要存在于肝脏中，最初发现它们是肝脏ILC亚群，也存在于其他淋巴和非淋巴组织中。越来越多的证据表明，ILC1在宿主保护和免疫调节中发挥着重要而独特的作用。然而，组织驻留ILC1的病理生理作用在很大程度上仍然不清楚。在这篇综述中，我们总结了新出现的证据表明，ILC1不仅有助于炎症，以防止病原体，但也促进组织保护和代谢。我们强调了ILC1在其驻留组织中的独特功能。
Innate lymphoid cells (ILCs) are tissue-resident innate lymphocytes that have functions to protect the hosts against pathogens and that regulate tissue inflammation and homeostasis. ILC subsets rapidly produce particular cytokines in response to infection, inflammation, and tissue injury at the local environment. Type 1 ILCs (ILC1s) promptly and abundantly produce interferon (IFN)-γ but lack appreciable cytotoxic activity. ILC1s share many phenotypic, developmental, and functional characteristics with natural killer (NK) cells, which are circulating innate lymphocytes with potent natural cytotoxicity. However, recent studies have established ILC1s as distinct from NK cells. ILC1s predominantly reside in the liver—they initially were discovered as a liver-resident ILC subset—as well as in other lymphoid and non-lymphoid tissues. Accumulating evidence has demonstrated that ILC1s play an important and unique role in host protection and in immunomodulation in their resident organs. However, the pathophysiological role of tissue-resident ILC1s remains largely unclear. In this review, we summarize emerging evidence showing that ILC1s not only contribute to inflammation to protect against pathogens but also promote tissue protection and metabolism. We highlight a unique function of ILC1s in their resident tissues.
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影响因子：
32.4
作者：
Colonna M
通讯作者：
Colonna M
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
影响因子：
32.4
作者：
Bernink, Jochem H.;Krabbendam, Lisette;Spits, Hergen
通讯作者：
Spits, Hergen
DOI：
10.1073/pnas.1423244112
发表时间：
2015-04-21
影响因子：
11.1
作者：
Constantinides, Michael G.;Gudjonson, Herman;Bendelac, Albert
通讯作者：
Bendelac, Albert
影响因子：
30.5
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
通讯作者：
Spits, Hergen