T2 texture index of cartilage can predict early symptomatic OA progression: data from the osteoarthritis initiative.
T2 texture index of cartilage can predict early symptomatic OA progression: data from the osteoarthritis initiative.
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DOI：
10.1016/j.joca.2013.06.007
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发表时间：
2013-10
影响因子：
7
通讯作者：
Mosher, T. J.
中科院分区：
文献类型：
--
作者：
Urish, K. L.;Keffalas, M. G.;Durkin, J. R.;Miller, D. J.;Chu, C. R.;Mosher, T. J.
有兴趣使用磁共振成像（MRI）来识别骨关节炎（OA）的放射学检查前变化和指示疾病进展风险的特征。本研究的目的是识别来自MRI T2图的图像特征，这些特征可以准确预测有膝关节OA风险的受试者的OA症状发作。从骨关节炎倡议（OAI）对照队列和发病率队列中选择患者，并根据总WOMAC评分从基线至3年随访的变化进行分层（80例非OA进展和88例症状性OA进展患者）。对于每个患者，从基线软骨T2图测量一系列图像纹理特征。然后训练线性判别函数和特征缩减方法，以基于22个图像特征来量化纹理度量，软骨的T2纹理指数（TIC），以识别T2异质性的复合标记。在非进展和症状性OA进展人群之间观察到基线T2 TIC的统计学显著差异。基线T2 TIC区分WOMAC评分OA恶化的受试者，准确度在71%-76%之间。T2 TIC差异主要局限于与膝关节机械轴相关的优势膝关节间室。用T2 TIC指数测量的软骨T2的基线异质性能够区分和预测在3年随访时WOMAC评分恶化的个体。
There is an interest in using Magnetic Resonance Imaging (MRI) to identify pre-radiographic changes in osteoarthritis (OA) and features that indicate risk for disease progression. The purpose of this study is to identify image features derived from MRI T2 maps that can accurately predict onset of OA symptoms in subjects at risk for incident knee OA. Patients were selected from the Osteoarthritis Initiative (OAI) control cohort and incidence cohort and stratified based on the change in total WOMAC score from baseline to three year follow-up (80 non-OA progression and 88 symptomatic OA progression patients). For each patient, a series of image texture features were measured from the baseline cartilage T2 map. A linear discriminant function and feature reduction method was then trained to quantify a texture metric, the T2 texture index of cartilage (TIC), based on 22 image features, to identify a composite marker of T2 heterogeneity. Statistically significant differences were seen in the baseline T2 TIC between the non-progression and symptomatic OA progression populations. The baseline T2 TIC differentiates subjects that develop worsening of their WOMAC score OA with an accuracy between 71% and 76%. The T2 TIC differences were predominantly localized to a dominant knee compartment that correlated with the mechanical axis of the knee. Baseline heterogeneity in cartilage T2 as measured with the T2 TIC index is able to differentiate and predict individuals that will develop worsening of their WOMAC score at 3-year follow-up.
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影响因子：
7
作者：
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