Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome.
Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome.
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DOI：
10.1016/j.neurobiolaging.2021.07.016
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发表时间：
2021-11
影响因子：
4.2
通讯作者：
Hartley SL
中科院分区：
文献类型：
--
作者：
Fleming V;Piro-Gambetti B;Patrick A;Zammit M;Alexander A;Christian BT;Handen B;Cohen A;Klunk W;Laymon C;Ances BM;Plante DT;Okonkwo O;Hartley SL
患有唐氏综合症(DS)的成年人有患阿尔茨海默病的风险。然而，尽管有相同的21三体，但发病年龄存在差异。这种变异性可能意味着其他因素，如生活方式，会影响认知老化和疾病发生的时间。本研究通过正电子发射断层扫描、淀粉样蛋白β和Tau以及扩散张力成像测量61例非痴呆成人DS患者的脑白质完整性，评估了日常生活体力活动与认知功能和早期阿尔茨海默病病理之间的关系。久坐行为和中等到剧烈活动的时间百分比与认知功能相关(分别为负和正)(r=−.472到.572，p<；0.05)。无论是久坐的行为还是中等到剧烈的活动都与淀粉样蛋白β或tau相关，但两者都与上下纵束的白质完整性有关(分数各向异性：r=−.397至−.419，p<；0.05；平均弥散率：r=.400，p<；0.05)。需要进行纵向研究，以确定体育活动是否促进DS患者的健康衰老。
Adults with Down syndrome (DS) are at risk for Alzheimer’s disease. Despite sharing trisomy 21, however, there is variability in the age of disease onset. This variability may mean that other factors, such as lifestyle, influence cognitive aging and disease timing. The present study assessed the association between everyday life physical activity using an actigraph accelerometer and cognitive functioning and early Alzheimer’s disease pathology via positron emission tomography amyloid-β and tau and diffusion tension imaging measures of white matter integrity in 61 non-demented adults with DS. Percent time in sedentary behavior and in moderate-to-vigorous activity were associated (negatively and positively, respectively) with cognitive functioning (r = −.472 to .572, p <.05). Neither sedentary behavior nor moderate-to-vigorous activity were associated with amyloid-β or tau, but both were associated with white matter integrity in the superior and inferior longitudinal fasciculus (Fractional Anisotropy: r = −.397 to −.419, p < .05; Mean Diffusivity: r = .400, p < .05). Longitudinal studies are needed to determine if physical activity promotes healthy aging in DS.
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影响因子：
3.6
作者：
Chen, C. -C. (J. J. );Ringenbach, S. D. R.
通讯作者：
Ringenbach, S. D. R.
影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
4.2
作者：
Hartley SL;Handen BL;Devenny D;Mihaila I;Hardison R;Lao PJ;Klunk WE;Bulova P;Johnson SC;Christian BT
通讯作者：
Christian BT
DOI：
10.1097/00005768-199805000-00021
发表时间：
1998-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Freedson, PS;Melanson, E;Sirard, J
通讯作者：
Sirard, J
影响因子：
4
作者：
Doughertya, Ryan J.;Schultz, Stephanie A.;Okonkwo, Ozioma C.
通讯作者：
Okonkwo, Ozioma C.