Dose evaluation of inter- and intra-fraction prostate motion in extremely hypofractionated intensity-modulated proton therapy for prostate cancer.
Dose evaluation of inter- and intra-fraction prostate motion in extremely hypofractionated intensity-modulated proton therapy for prostate cancer.
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DOI：
10.1016/j.phro.2023.100474
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发表时间：
2023-07
影响因子：
--
通讯作者：
Aluwini, Shafak
中科院分区：
文献类型：
--
作者：
Feng, Sen-Quan;Brouwer, Charlotte L.;Korevaar, Erik W.;Vapiwala, Neha;Wang, Ken Kang-Hsin;Deville, Curtiland, Jr.;Langendijk, Johannes A.;Both, Stefan;Aluwini, Shafak
关键词：
合成计算机断层扫描图像被用来模拟实时前列腺位置的4D模拟方法的分次前列腺运动的发展前列腺运动有最小的剂量影响，以鲁棒优化质子治疗分次间和分次内前列腺运动可以恶化剂量分布在极低分次调强质子治疗。我们使用验证CT和从1024个部分内前列腺运动记录计算的前列腺运动数据来开发基于体素的4维方法，该方法具有1 s的时间分辨率，以评估前列腺运动的剂量影响。100次部分模拟的示例显示，运动对计划剂量的影响最小，95%场景中的累积剂量满足靶区覆盖的临床目标（D95 > 37.5戈伊）。该方法可作为临床环境中保证计划质量的补充措施。
Synthetic computed tomography images were used to simulate real-time prostate position A 4D simulation method of intra-fractional prostate motion was developed Prostate motion had minimal dose impact to robustly optimized proton therapy Inter- and intra-fractional prostate motion can deteriorate the dose distribution in extremely hypofractionated intensity-modulated proton therapy. We used verification CTs and prostate motion data calculated from 1024 intra-fractional prostate motion records to develop a voxel-wise based 4-dimensional method, which had a time resolution of 1 s, to assess the dose impact of prostate motion. An example of 100 fractional simulations revealed that motion had minimal impact on planning dose, the accumulated dose in 95 % of the scenarios fulfilled the clinical goals for target coverage (D95 > 37.5 Gy). This method can serve as a complementary measure in clinical setting to guarantee plan quality.
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DOI：
10.7759/cureus.2442
发表时间：
2018-04-06
期刊：
Cureus
影响因子：
--
作者：
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通讯作者：
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DOI：
10.1016/j.ijrobp.2006.10.026
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影响因子：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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