Patterns of neural connectivity during an attention bias task moderate associations between early childhood temperament and internalizing symptoms in young adulthood.
Patterns of neural connectivity during an attention bias task moderate associations between early childhood temperament and internalizing symptoms in young adulthood.
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DOI：
10.1016/j.biopsych.2013.01.036
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发表时间：
2013-08-15
影响因子：
10.6
通讯作者：
Perez-Edgar, Koraly
中科院分区：
文献类型：
--
作者：
Hardee, Jillian E.;Benson, Brenda E.;Bar-Haim, Yair;Mogg, Karin;Bradley, Brendan P.;Chen, Gang;Britton, Jennifer C.;Ernst, Monique;Fox, Nathan A.;Pine, Daniel S.;Perez-Edgar, Koraly
Biased attention to threat is found in both individuals with anxiety symptoms and children with the childhood temperament of behavioral inhibition (BI). Although perturbed fronto-amygdala function is implicated in biased attention among anxious individuals, no work has examined the neural correlates of attention biases in BI. Work in this area may clarify underlying mechanisms for anxiety in a sample at risk for internalizing disorders. We examined the relations among early childhood BI, fronto-amygdala connectivity during an attention bias task in young adulthood, and internalizing symptoms, assessed in young adulthood. Children were assessed for BI at multiple age points from infancy through age seven. Based on a composite of observational and maternal report data, we selected 21 young adults classified as having a history of BI and 23 classified as non-BI for this study (N=44). Participants completed an event-related fMRI attention-bias task involving threat (angry faces) and neutral trials. Internalizing symptoms were assessed by self-report and diagnostic interviews. The young adults characterized in childhood with BI exhibited greater strength in threat-related connectivity than non-behaviorally inhibited young adults. Between-group differences manifested in connections between the amygdala and two frontal regions: dorsolateral prefrontal cortex and anterior insula. Amygdala-insula connectivity also interacted with childhood BI to predict young adult internalizing symptoms. BI during early childhood predicts differences as young adults in threat and attention-related fronto-amygdala connectivity. Connectivity strength, in turn, moderated the relations between early BI and later psychopathology.
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影响因子：
2.6
作者：
Helfinstein, Sarah M.;Benson, Brenda;Ernst, Monique
通讯作者：
Ernst, Monique
DOI：
10.1097/chi.0b013e3181ae09df
发表时间：
2009-09
影响因子：
13.3
作者：
Chronis-Tuscano A;Degnan KA;Pine DS;Perez-Edgar K;Henderson HA;Diaz Y;Raggi VL;Fox NA
通讯作者：
Fox NA
影响因子：
5.7
作者：
Cohen, MS
通讯作者：
Cohen, MS
影响因子：
10.6
作者：
Hakamata, Yuko;Lissek, Shmuel;Bar-Haim, Yair;Britton, Jennifer C.;Fox, Nathan A.;Leibenluft, Ellen;Ernst, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
DOI：
10.1176/appi.ajp.2009.09070931
发表时间：
2010-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Etkin A;Prater KE;Hoeft F;Menon V;Schatzberg AF
通讯作者：
Schatzberg AF