Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition.
Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition.
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DOI：
10.1084/jem.184.5.2025
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发表时间：
1996-11-01
期刊：
影响因子：
--
通讯作者：
Nussenzweig MC
中科院分区：
文献类型：
--
作者：
Papavasiliou F;Jankovic M;Nussenzweig MC
To examine the role of light chains in early B cell development we combined RAG-1 and lambda 5 mutations to produce mice that expressed neither conventional nor surrogate light chains (RAG-1-/-, lambda 5-/- ). Unique heavy and light chain genes were then introduced into the double and single mutant backgrounds. Membrane immunoglobulin (Ig)mu (mIg mu) associated with Ig alpha-Ig beta but was unable to activate the pre-B cell transition in RAG-1-/-lambda 5-/- mice. Either lambda 5 or kappa light chains were sufficient to complement this deficiency. Therefore light chains are absolutely required for a functional Ig signaling module in early B cell development. Our data provide direct evidence for the existence of two pathways for induction of early B cell development: one which is activated through surrogate light chains and mIg mu, and an alternative pathway which uses conventional light chains and mIg mu.
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DOI：
10.1016/0167-5699(94)90267-4
发表时间：
1994-09-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
PLEIMAN, CM;DAMBROSIO, D;CAMBIER, JC
通讯作者：
CAMBIER, JC
影响因子：
64.5
作者：
KITAMURA, D;KUDO, A;RAJEWSKY, K
通讯作者：
RAJEWSKY, K
影响因子：
64.8
作者：
HAAS, IG;WABL, M
通讯作者：
WABL, M
影响因子：
56.9
作者：
NUSSENZWEIG, MC;SHAW, AC;LEDER, P
通讯作者：
LEDER, P
影响因子：
9.2
作者：
CORCOS, D;DUNDA, O;JAMI, J
通讯作者：
JAMI, J