Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study.
Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study.
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DOI：
10.1186/2040-2392-2-13
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发表时间：
2011-08-02
期刊：
影响因子：
6.2
通讯作者：
Van de Water J
中科院分区：
文献类型：
--
作者：
Goines PE;Croen LA;Braunschweig D;Yoshida CK;Grether J;Hansen R;Kharrazi M;Ashwood P;Van de Water J
自闭症谱系障碍（ASD）患者及其家庭成员的免疫异常已被记录。目前尚不清楚怀孕期间母体免疫状况是否与患有ASD或其他神经发育障碍的孩子的风险有关。使用Luminex技术，在从妊娠15至19周的妇女收集的库存血清中测量17种细胞因子和趋化因子的水平，所述妇女生下最终诊断为（1）ASD（n = 84）、（2）发育迟缓（DD）但非自闭症（n = 49）或（3）无已知发育障碍（一般人群（GP）; n = 159）的孩子。通过多变量logistic回归分析，估计与母体细胞因子和趋化因子水平相关的ASD和DD风险。妊娠中期母体血清中IFN-γ、IL-4和IL-5浓度升高与ASD风险增加50%显著相关，无论ASD发作类型和是否存在智力残疾。相比之下，IL-2、IL-4和IL-6浓度升高与无自闭症DD风险增加显著相关。血清IFN-γ、IL-4和IL-5升高的情况在生育了随后诊断为ASD的孩子的妇女中更常见。IL-2、IL-4和IL-6增加的另一种情况在生下随后诊断为DD而无自闭症的孩子的妇女中更常见。需要进一步的调查，以表征这些不同的母体免疫表型之间的关系，并评估其对神经发育的影响。
Immune anomalies have been documented in individuals with autism spectrum disorders (ASDs) and their family members. It is unknown whether the maternal immune profile during pregnancy is associated with the risk of bearing a child with ASD or other neurodevelopmental disorders. Using Luminex technology, levels of 17 cytokines and chemokines were measured in banked serum collected from women at 15 to 19 weeks of gestation who gave birth to a child ultimately diagnosed with (1) ASD (n = 84), (2) a developmental delay (DD) but not autism (n = 49) or (3) no known developmental disability (general population (GP); n = 159). ASD and DD risk associated with maternal cytokine and chemokine levels was estimated by using multivariable logistic regression analysis. Elevated concentrations of IFN-γ, IL-4 and IL-5 in midgestation maternal serum were significantly associated with a 50% increased risk of ASD, regardless of ASD onset type and the presence of intellectual disability. By contrast, elevated concentrations of IL-2, IL-4 and IL-6 were significantly associated with an increased risk of DD without autism. The profile of elevated serum IFN-γ, IL-4 and IL-5 was more common in women who gave birth to a child subsequently diagnosed with ASD. An alternative profile of increased IL-2, IL-4 and IL-6 was more common for women who gave birth to a child subsequently diagnosed with DD without autism. Further investigation is needed to characterize the relationship between these divergent maternal immunological phenotypes and to evaluate their effect on neurodevelopment.
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影响因子：
3.4
作者：
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