Sex-related Differences in Stress Reactivity and Cingulum White Matter.
Sex-related Differences in Stress Reactivity and Cingulum White Matter.
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DOI：
10.1016/j.neuroscience.2021.02.014
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发表时间：
2021-04-01
期刊：
影响因子：
3.3
通讯作者：
Knight DC
中科院分区：
文献类型：
--
作者：
Wheelock MD;Goodman AM;Harnett NG;Wood KH;Mrug S;Granger DA;Knight DC
前额叶皮层和边缘系统是压力和焦虑神经回路的重要组成部分。这些大脑区域由支持神经通信的白色物质束连接，包括扣带、钩束和穹窿/终纹。确定压力反应性和这些白色物质束之间的关系，可能会提供新的洞察力的因素，压力敏感性和弹性。因此，本研究探讨了性别差异之间的关系的应激反应性和广义分数各向异性（GFA）的白色物质束，前额叶皮层和边缘系统。在104名年轻人（55名男性，49名女性;平均年龄= 18.87 SEM = 0.08）中收集弥散加权图像并完成确定性纤维束成像。参与者还完成了自我报告问卷（例如，特质焦虑）和捐赠的唾液（后来测定皮质醇）之前，期间和之后的特里尔社会压力测试。结果显示，应激反应（皮质醇曲线下的面积增加）和GFA的扣带束不同的性别。具体来说，男性表现出更大的皮质醇反应性和更大的GFA内扣带回比女性。此外，还观察到性别、压力反应性和扣带回GFA之间的相互作用，其中男性表现出GFA与皮质醇反应性之间的正相关关系，而女性则表现出GFA与皮质醇反应性之间的负相关关系。最后，特质焦虑与穹窿/终纹的GFA呈正相关--穹窿/终纹是连接海马体/杏仁核和下丘脑的白色物质通路。这些发现促进了我们对压力反应个体差异的因素的理解。
The prefrontal cortex and limbic system are important components of the neural circuit that underlies stress and anxiety. These brain regions are connected by white matter tracts that support neural communication including the cingulum, uncinate fasciculus, and the fornix/stria-terminalis. Determining the relationship between stress reactivity and these white matter tracts may provide new insight into factors that underlie stress susceptibility and resilience. Therefore, the present study investigated sex differences in the relationship between stress reactivity and generalized fractional anisotropy (GFA) of the white matter tracts that link the prefrontal cortex and limbic system. Diffusion weighted images were collected and deterministic tractography was completed in 104 young adults (55 men, 49 women; mean age = 18.87 SEM = 0.08). Participants also completed self-report questionnaires (e.g., Trait Anxiety) and donated saliva (later assayed for cortisol) before, during, and after the Trier Social Stress Test. Results revealed that stress reactivity (area under the curve increase in cortisol) and GFA of the cingulum bundle varied by sex. Specifically, men demonstrated greater cortisol reactivity and greater GFA within the cingulum than women. Further, an interaction between sex, stress reactivity, and cingulum GFA was observed in which men demonstrated a positive relationship while women demonstrated a negative relationship between GFA and cortisol reactivity. Finally, trait anxiety was positively associated with the GFA of the fornix/stria terminalis - the white matter pathways that connect the hippocampus/amygdala to the hypothalamus. These findings advance our understanding of factors that underlie individual differences in stress reactivity.
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影响因子：
4.6
作者：
Eaton NR;Keyes KM;Krueger RF;Balsis S;Skodol AE;Markon KE;Grant BF;Hasin DS
通讯作者：
Hasin DS
DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
3.3
作者：
Het, Serkan;Schoofs, Daniela;Wolf, Oliver T.
通讯作者：
Wolf, Oliver T.
DOI：
10.1523/jneurosci.2335-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kim MJ;Whalen PJ
通讯作者：
Whalen PJ
影响因子：
3.2
作者：
KIRSCHBAUM, C;PIRKE, KM;HELLHAMMER, DH
通讯作者：
HELLHAMMER, DH