Caudal nuclei of the rat nucleus of the solitary tract differentially innervate respiratory compartments within the ventrolateral medulla.
Caudal nuclei of the rat nucleus of the solitary tract differentially innervate respiratory compartments within the ventrolateral medulla.
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DOI：
10.1016/j.neuroscience.2011.06.005
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发表时间：
2011-09-08
期刊：
影响因子：
3.3
通讯作者：
McCrimmon, D. R.
中科院分区：
文献类型：
--
作者：
Alheid, G. F.;Jiao, W.;McCrimmon, D. R.
关键词：
大量的呼吸、心血管、内脏和躯体传入通过孤立束核（NTS）传递到脑干（和前脑）。尽管NTS内部存在一定程度的重叠，但NTS中二级传入中继神经元驱动的中枢呼吸反射仍保持特异性。虽然针对NTS的呼吸相关事件的地形安排已被广泛研究，但它们在NTS之外的高阶脑干目标很少被精确定义。尽管如此，服务于血气稳态和气道保护性反射的各种脑干回路必须明确地接受来自NTS的不同神经支配，以引起刺激适当的行为反应。因此，我们研究了哪些特定的NTS核投射到腹侧延髓的腹侧呼吸柱（VRC）内的特定隔室的问题。我们对逆行示踪剂注射在VRC和附近控制自主神经功能的神经元组后的NTS标记的分析表明，与VRC的其余部分相比，对Bötzinger复合体和preBötzinger复合体的投射存在显著差异。具体来说，尾侧NTS，包括内侧孤立核的尾侧部分和NTS的相交部分相对密集地投射到后梯形核和吻侧腹侧髓核区域以及吻侧腹侧呼吸群，同时避开了中间的Bötzinger和preBötzinger复合体。脑后区表现出一种类似于尾侧、内侧和联合NTS核的投射模式。另外，我们还注意到NTS外侧核向不同VRC隔室的差异投射。
A substantial array of respiratory, cardiovascular, visceral and somatic afferents are relayed via the nucleus of the solitary tract (NTS) to the brainstem (and forebrain). Despite some degree of overlap within the NTS, specificity is maintained in central respiratory reflexes driven by 2nd order afferent relay neurons in the NTS. While the topographical arrangement of respiratory-related afferents targeting the NTS has been extensively investigated, their higher order brainstem targets beyond the NTS has only rarely been defined with any precision. Nonetheless, the various brainstem circuits serving blood gas homeostasis and airway protective reflexes must clearly receive a differential innervation from the NTS in order to evoke stimulus appropriate behavioral responses. Accordingly, we have examined the question of which specific NTS nuclei project to particular compartments within the ventral respiratory column (VRC) of the ventrolateral medulla. Our analyses of NTS labeling after retrograde tracer injections in the VRC and the nearby neuronal groups controlling autonomic function indicate a significant distinction between projections to the Bötzinger complex and preBötzinger complex compared to the remainder of the VRC. Specifically, the caudomedial NTS, including caudal portions of the medial solitary nucleus and the commissural division of NTS project relatively densely to the region of the retrotrapezoid nucleus and rostral ventrolateral medullary nucleus as well as to the rostral ventral respiratory group while avoiding the intervening Bötzinger and preBötzinger complexes. Area postrema appears to demonstrate a pattern of projections similar to that of caudal medial and commissural NTS nuclei. Other, less pronounced differential projections of lateral NTS nuclei to the various VRC compartments are additionally noted.
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