Assessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders.
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders.
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DOI：
10.1002/hbm.22559
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发表时间：
2014-11
影响因子：
4.8
通讯作者：
Kochunov, Peter
中科院分区：
文献类型：
--
作者：
Acheson, Ashley;Wijtenburg, S. Andrea;Rowland, Laura M.;Winkler, Anderson M.;Gaston, Frank;Mathias, Charles W.;Fox, Peter T.;Lovallo, William R.;Wright, Susan N.;Hong, L. Elliot;Dougherty, Donald M.;Kochunov, Peter
有物质使用障碍家族史的个体（FH+）比没有这种家族史的同龄人（FH-）更容易发生物质使用障碍，这种脆弱性与受影响亲属的数量（FH密度）成正比。在一般人群中，发生物质使用障碍的风险在青春期至成年早期达到高峰，这被认为与额皮质和额纹状体功能回路的成熟延迟有关。我们假设FH+青年和青年人的额皮质和额纹状体白色物质束的髓鞘形成受损。我们检查了80名FH+和34名FH−青年（12.9±1.0岁）以及25名FH+和30名FH−青年（24.3±3.4岁）的分数各向异性（FA）数据。FH+青年在额皮质和额纹状体束以及包括前、上级和后放射冠和上级额枕束在内的顶叶皮质束中具有较低的FA值。此外，FA值与FH密度呈负相关。FH+成人有较低的FA值在两个额皮质束：胼胝体和前冠辐射，也显着的负相关FA和FH密度在这些相同的束。在两组中，较低的FA值对应于较高的径向扩散率，表明轴突髓鞘形成减少。我们将我们的发现解释为额叶白色物质髓鞘形成受损与FH密度成正比的证据。我们的数据表明，赤字可能会随着年龄的增长而部分解决，与年龄相关的物质使用障碍风险下降平行。
Individuals with a family history of substance use disorders (FH+) are at a greater risk of developing substance use disorders than their peers with no such family histories (FH−) and this vulnerability is proportional to the number of affected relatives (FH density). The risk for developing substance use disorders peaks during adolescence to early adulthood in the general population, and that is thought to be related to delayed maturation of frontocortical and frontostriatal functional circuits. We hypothesized that FH+ youth and young adults have impaired myelination of frontocortical and frontostriatal white matter tracts. We examined fractional anisotropy (FA) data in 80 FH+ and 34 FH− youths (12.9±1.0 years) and in 25 FH+ and 30 FH− young adults (24.3±3.4 years). FH+ youths had lower FA values in both frontocortical and frontostriatal tracts as well as parietocortical tracts including the anterior, superior and posterior corona radiata and the superior frontal-occipital fasciculus. Moreover, FA values in these tracts were negatively correlated with FH density. FH+ adults had lower FA values in two frontocortical tracts: the genu of the corpus callosum and anterior corona radiata and also significant negative correlations between FA and FH density in these same tracts. In both groups, lower FA values corresponded to higher radial diffusivity suggesting reduced axonal myelination. We interpreted our findings as evidence for impaired myelination of frontal white matter that was proportional to FH density. Our data suggest that deficits may partially resolve with age, paralleling an age-related decline in risk for developing substance use disorders.
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DOI：
10.1017/sl461145706007395
发表时间：
2007-12-01
影响因子：
4.8
作者：
Chung, Ain;Lyoo, In Kyoon;Renshaw, Perry F.
通讯作者：
Renshaw, Perry F.
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF
DOI：
10.15288/jsa.2003.64.195
发表时间：
2003-03-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Corral, M;Holguín, SR;Cadaveira, F
通讯作者：
Cadaveira, F
影响因子：
4.2
作者：
Clark, DB;Cornelius, JR;Tarter, RE
通讯作者：
Tarter, RE
影响因子：
1.9
作者：
FALCONER, DS
通讯作者：
FALCONER, DS