Population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space.
Population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space.
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DOI：
10.1007/s00429-017-1463-6
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发表时间：
2017-12
影响因子：
3.1
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Feng L;Jeon T;Yu Q;Ouyang M;Peng Q;Mishra V;Pletikos M;Sestan N;Miller MI;Mori S;Hsiao S;Liu S;Huang H
恒河猴（Macaca mulatta）是应用最广泛的非人灵长类动物，其动物模型在神经生物学研究中具有不可替代的地位。然而，目前还没有人口平均猕猴大脑扩散张量成像（DTI）图谱，包括全面的灰质和白质标记以及指导侵入性实验程序的骨和面部标志。猕猴白质束通路和微观结构很少被记录。在这里，我们建立了一个群体平均猕猴大脑图谱，将高分辨率的离体 DTI 集成到体内空间中，包含骨和面部标志，以及主要白质束的微观结构和三维路径。获得了 10 只恒河猴大脑的体内 MRI/DTI 和离体（死后）DTI。通过将死后高分辨率 DTI 数据转换到体内空间获得单受试者猕猴脑 DTI 模板。然后在体内单受试者模板空间中对 10 只猕猴大脑的离体 DTI 进行平均，以生成群体平均猕猴大脑 DTI 图集。使用基于 DTI 的纤维束描记术追踪白质纤维束。 118 个神经结构，包括所有皮层回、白质束和皮层下核，均在群体平均 DTI 衍生图上手动标记。测量了所追踪的白质束的分数各向异性、轴向、径向和平均扩散率的体内微观结构指标。集成到体内空间的群体平均数字图谱可用于自动标记实验猕猴大脑。骨和面部标志将可用于指导侵入性手术。 DTI 测量提供了对不同白质束的异质微观结构轮廓的独特见解。
Animal models of the rhesus macaque (Macaca mulatta), the most widely used nonhuman primate, have been irreplaceable in neurobiological studies. However, a population-averaged macaque brain diffusion-tensor-imaging (DTI) atlas, including comprehensive gray and white matter labeling as well as bony and facial landmarks guiding invasive experimental procedures, is not available. The macaque white matter tract pathways and microstructures have been rarely recorded. Here, we established a population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space incorporating bony and facial landmarks, and delineated microstructures and three-dimensional pathways of major white matter tracts. In vivo MRI/DTI and ex vivo (postmortem) DTI of 10 rhesus macaque brains were acquired. Single-subject macaque brain DTI template was obtained by transforming the postmortem high resolution DTI data into in vivo space. Ex vivo DTI of 10 macaque brains was then averaged in the in vivo single-subject template space to generate population-averaged macaque brain DTI atlas. The white matter tracts were traced with DTI-based tractography. 118 neural structures including all cortical gyri, white matter tracts and subcortical nuclei, were labeled manually on population-averaged DTI-derived maps. The in vivo microstructural metrics of fractional anisotropy, axial, radial and mean diffusivity of the traced white matter tracts were measured. Population-averaged digital atlas integrated into in vivo space can be used to label the experimental macaque brain automatically. Bony and facial landmarks will be available for guiding invasive procedures. The DTI-metric measurements offer unique insights into heterogeneous microstructural profiles of different white matter tracts.
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影响因子：
5.7
作者：
Adluru, Nagesh;Zhang, Hui;Fox, Andrew S.;Shelton, Steven E.;Ennis, Chad M.;Bartosic, Anne M.;Oler, Jonathan A.;Tromp, Do P. M.;Zakszewski, Elizabeth;Gee, James C.;Kalin, Ned H.;Alexander, Andrew L.
通讯作者：
Alexander, Andrew L.
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
7.6
作者：
Huang, Hao;Gundapuneedi, Tejasvi;Rao, Uma
通讯作者：
Rao, Uma
恒河猴婴儿期晚期大脑发育和苯环己哌啶的影响：纵向 MRI 和 DTI 研究
影响因子：
5.7
作者：
Liu, Cirong;Tian, Xiaoguang;Wang, Jianhong
通讯作者：
Wang, Jianhong
影响因子：
3.5
作者：
Lerch JP;Gazdzinski L;Germann J;Sled JG;Henkelman RM;Nieman BJ
通讯作者：
Nieman BJ