Structures and cytotoxic evaluation of new and known acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge.
Structures and cytotoxic evaluation of new and known acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge.
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DOI：
10.1021/np3008446
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发表时间：
2013-03-22
影响因子：
5.1
通讯作者：
Crews P
中科院分区：
文献类型：
--
作者：
Mejia EJ;Magranet LB;De Voogd NJ;Tendyke K;Qiu D;Shen YY;Zhou Z;Crews P
从采自美属萨摩亚的一种岩藻海绵中分离得到4个新化合物（-）-岩藻酸A-D（1-4）和5个已知同系物pellynols A（5）、C（6）、D（7）、F（8）和I（9）。通过对人肺癌细胞（H460）的细胞毒性指导分离工作。C31-C33聚乙炔（1-9）的结构基于1D-和2D-NMR分析、质谱和比旋光度值的比较来确定。发现化合物1-9具有广泛的细胞毒性，对癌细胞具有有限的选择性，因为它们对A2058（黑素瘤）、H522-T1（肺）和H460（肺）人癌细胞系以及IMR-90静止人成纤维细胞都具有中等活性。
Four new compounds, (−)-petrosynoic acids A–D (1–4), and five known congeners, pellynols A (5), C (6), D (7), F (8), and I (9) were isolated from a Petrosia sp. marine sponge collected in American Samoa. Isolation work was guided by cytotoxicity against human lung cancer cells (H460). The structures of the C31-C33 polyacetylenes (1–9) were determined on the basis of 1D- and 2D-NMR analysis, mass spectrometry, and comparison of specific rotation values. Compounds 1–9 were found to be broadly cytotoxic with limited selectivity for cancer cells as they were all moderately active against the A2058 (melanoma), H522-T1 (lung), and H460 (lung) human cancer cell lines as well as IMR-90 quiescent human fibroblast cells.
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影响因子：
5.7
作者：
Kuznetsov G;Xu Q;Rudolph-Owen L;Tendyke K;Liu J;Towle M;Zhao N;Marsh J;Agoulnik S;Twine N;Parent L;Chen Z;Shie JL;Jiang Y;Zhang H;Du H;Boivin R;Wang Y;Romo D;Littlefield BA
通讯作者：
Littlefield BA
影响因子：
5.1
作者：
Kim, JS;Lim, YJ;Lee, H
通讯作者：
Lee, H
影响因子：
5.1
作者：
Nishimura, S;Matsunaga, S;Fusetani, N
通讯作者：
Fusetani, N
影响因子：
5.1
作者：
Johnson, Tyler A.;Morgan, Micaela V. C.;Crews, Phillip
通讯作者：
Crews, Phillip
影响因子：
5.1
作者：
Lansdell TA;Hewlett NM;Skoumbourdis AP;Fodor MD;Seiple IB;Su S;Baran PS;Feldman KS;Tepe JJ
通讯作者：
Tepe JJ