Human whole-blood (1)H2O longitudinal relaxation with normal and high-relaxivity contrast reagents: influence of trans-cell-membrane water exchange.
Human whole-blood (1)H2O longitudinal relaxation with normal and high-relaxivity contrast reagents: influence of trans-cell-membrane water exchange.
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DOI：
10.1002/mrm.25064
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发表时间：
2014-12
影响因子：
3.3
通讯作者：
Maki, Jeffrey H.
中科院分区：
文献类型：
--
作者：
Wilson, Gregory J.;Woods, Mark;Springer, Charles S.;Bastawrous, Sarah;Bhargava, Puneet;Maki, Jeffrey H.
在对比增强磁共振血管成像（CE-MRA）中，需要准确表征全血中造影剂（CR）的纵向弛豫率以预测动脉信号强度。本研究在生理动脉条件下，在1.5和3.0T下测量了离体全血和血浆中非蛋白结合和蛋白结合CR浓度范围内的纵向弛豫速率常数（R1）。在0至18 mM [mmol（CR）/L（血液）]范围内测量钆特醇、钆布醇、钆贝酸盐和钆磷维司的弛豫率：后者是CE-MRA中预期的上限。在血浆中，钆贝酸盐和钆磷维塞的1H 2 O R1 [CR]依赖性为非线性，继发于CR与血清大分子白蛋白的相互作用，并通过有效1：1结合化学计量的分析表达式进行了充分描述。在全血中，1H 2 O R1 [CR]-依赖性对于所有CR都是显著非线性的，并且仅使用先验参数值通过血浆和细胞内空间之间的水分子平衡交换的表达式进行了良好的预测。在全血中，1H 2 O R1在0至18 mM CR范围内与[CR]呈非线性关系。通过红细胞和血浆室之间的水交换很好地描述了非线性，并且对于高弛豫率CR特别明显。
Accurate characterization of contrast reagent (CR) longitudinal relaxivity in whole blood is required to predict arterial signal intensity in contrast-enhanced MR angiography (CE-MRA). This study measured the longitudinal relaxation rate constants (R1) over a range of non-protein-binding and protein-binding CR concentrations in ex vivo whole blood and plasma at 1.5 and 3.0T under physiologic arterial conditions. Relaxivities of gadoteridol, gadobutrol, gadobenate, and gadofosveset were measured for [CR] from 0 to 18 mM [mmol(CR)/L(blood)]: the latter being the upper limit of what may be expected in CE-MRA. In plasma, the 1H2O R1 [CR]-dependence was non-linear for gadobenate and gadofosveset secondary to CR interactions with the serum macromolecule albumin, and was well described by an analytical expression for effective 1:1 binding stoichiometry. In whole blood, the 1H2O R1 [CR]-dependence was markedly non-linear for all CRs, and was well-predicted by an expression for equilibrium exchange of water molecules between plasma and intracellular spaces using a priori parameter values only. In whole blood, 1H2O R1 exhibits a non-linear relationship with [CR] over 0 to 18 mM CR. The non-linearity is well described by exchange of water between erythrocyte and plasma compartments, and is particularly evident for high relaxivity CRs.
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影响因子：
--
作者：
HERBST, MD;GOLDSTEIN, JH
通讯作者：
GOLDSTEIN, JH
影响因子：
3.4
作者：
Zhang, Yajie;Poirier-Quinot, Marie;Balschi, James A.
通讯作者：
Balschi, James A.
影响因子：
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作者：
Henrotte, Virginie;Muller, Robert N.;Elst, Luce Vander
通讯作者：
Elst, Luce Vander
影响因子：
6.7
作者：
Rohrer, M;Bauer, H;Weinmann, HJ
通讯作者：
Weinmann, HJ
影响因子：
2.2
作者：
Li, Xin;Priest, Ryan A.;Woodward, William J.;Siddiqui, Faisal;Beer, Tomasz M.;Garzotto, Mark G.;Rooney, William D.;Springer, Charles S., Jr.
通讯作者：
Springer, Charles S., Jr.