Prenatal and perinatal risk factors for neuroblastoma.

Prenatal and perinatal risk factors for neuroblastoma.
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DOI:
10.1002/ijc.23847
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发表时间:
2008-12-15
影响因子:
6.4
通讯作者:
Fraumeni JF Jr
Fraumeni JF Jr
中科院分区:
医学1区
文献类型:
--
作者:
Bluhm E;McNeil DE;Cnattingius S;Gridley G;El Ghormli L;Fraumeni JF Jr

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神经母细胞瘤是一种罕见的儿童胚胎肿瘤,其危险因素尚不清楚。采用巢式病例对照设计,我们调查了产前,围产期和新生儿的危险因素,详细链接245例儿童神经母细胞瘤的情况下,在瑞典癌症登记诊断1973年至1995年与瑞典医学出生登记。从出生登记处随机选择每例病例的5名活对照,按性别和年龄进行匹配。风险增加与妊娠期间母体贫血(比值比(OR)=2.95,95%置信区间(CI):1.53,5.69)、新生儿呼吸窘迫(OR=3.61,95% CI:1.41,9.24)和低(低于或等于7)1分钟Apgar评分(OR=2.23,95% CI:1.41,3.52)相关。增加的风险仅限于一岁以前诊断的病例。产前、围产期和新生儿窘迫的标志物可能与婴儿期神经母细胞瘤相关,但与1岁或以上的诊断无关。
Neuroblastoma is a rare embryonal tumor of childhood for which risk factors are not well known. Using a nested case-control design, we investigated prenatal, perinatal, and neonatal risk factors in detail by linking 245 pediatric neuroblastoma cases identified in the Swedish Cancer Register diagnosed 1973-1995 with the Swedish Medical Birth Register. Five living controls per case were randomly selected from the birth registry, matched by gender and age. Increased risks were associated with maternal anemia during pregnancy (odds ratio (OR)=2.95, 95% confidence interval (CI): 1.53, 5.69), neonatal respiratory distress (OR=3.61, 95% CI: 1.41, 9.24), and low (below or equal to 7) 1-minute Apgar score (OR=2.23, 95% CI:1.41, 3.52). Increased risks were limited to cases diagnosed before one year of age. Markers of prenatal, perinatal, and neonatal distress may be associated with neuroblastoma in infancy, but not with diagnoses at 1 year or above.
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