Biocompatible polydopamine-encapsulated gadolinium-loaded carbon nanotubes for MRI and color mapping guided photothermal dissection of tumor metastasis
Biocompatible polydopamine-encapsulated gadolinium-loaded carbon nanotubes for MRI and color mapping guided photothermal dissection of tumor metastasis
复制标题
生物相容性聚多巴胺封装的载钆碳纳米管，用于 MRI 和彩色绘图引导肿瘤转移的光热解剖
DOI：
10.1016/j.carbon.2016.10.096
复制
发表时间：
2017-02
期刊：
影响因子：
10.9
通讯作者：
Shun Shen
中科院分区：
文献类型：
--
作者：
Jiantao Chen;Huile Gao;Deliang Fu;Shun Shen
Owing to the convenient and visual advantages, dye mapping agents are the most popular lymph tracing agents in the current clinic practices. However, limit tissue penetration always leads to hardly detect deeper lymph nodes (LNs), such as regional lymph nodes (RLNs). Therefore, exploring multimodal nanotheranostic agents for diagnosis and treatment of metastatic LNs are desired. In this study, polydopamine-encapsulated gadolinium-loaded multi-walled carbon nanotube (MWCNT-Gd@PDA) were strategically designed for dual-modality mapping guided photothermal therapy (PTT) by positive signal of magnetic resonance imaging (MRI) as well as deep black of the nanomaterials providing visual information. PDA, with excellent biocompatibility and biodegradability, can be easily deposited on many kinds of inorganic and organic materials to prepare functional materials. In order to prevent gadolinium ion escaping from the MWCNT, PDA shell was coated on the surface of MWCNT-Gd. Thus, the prepared MWCNT-Gd@PDA nanomaterials were lack of inherent biological toxicity. More importantly, under the guidance of dual-modality mapping, we demonstrated that primary tumors and RLNs could be simultaneously and effectively ablated by near-infrared irradiation to acquire the radical photothermal dissection. The results showed that our nanosystem possessed the precise spatial-temporal selectivity in comparison with conventional surgery and T2-MRI guided PTT.
登录
查看更多内容
影响因子：
13.3
作者：
Yang, Yanmei;Velmurugan, Bhaarathy;Xing, Bengang
通讯作者：
Xing, Bengang
纤维蛋白靶向肽 CREKA 缀合多壁碳纳米管用于肿瘤自放大光热治疗
影响因子：
14
作者：
Bo Zhang;Huafang Wang;Shun Shen;Xiaojian She;Wei Shi;Jun Chen;Qizhi Zhang;Yu Hu;Zhiqing Pang;Xinguo Jiang
通讯作者：
Xinguo Jiang
影响因子：
2.9
作者：
Zhou Z;Chen H;Lipowska M;Wang L;Yu Q;Yang X;Tiwari D;Yang L;Mao H
通讯作者：
Mao H
影响因子：
9.5
作者：
Sheng Wang;Qin Zhang;Peng Yang;Xiangrong Yu;Li-yong Huang;S. Shen;S. Cai
通讯作者：
Sheng Wang;Qin Zhang;Peng Yang;Xiangrong Yu;Li-yong Huang;S. Shen;S. Cai
PEDOT 纳米复合材料在 NIR I 和 II 窗口中介导双模态光动力和光热靶向灭菌
影响因子：
14
作者：
Li, Luoyuan;Liu, Yuxin;Zhou, Jing
通讯作者：
Zhou, Jing