Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study.
Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study.
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DOI：
10.1186/s12879-020-05681-5
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发表时间：
2020-12-21
影响因子：
3.7
通讯作者：
Lu FE
中科院分区：
文献类型：
--
作者：
Gong J;Dong H;Xia QS;Huang ZY;Wang DK;Zhao Y;Liu WH;Tu SH;Zhang MM;Wang Q;Lu FE
COVID-19具有高度传染性，危重患者的粗死亡率可达49%。炎症与疾病进展有关。该研究分析了轻症、重症和危重症患者的血液炎症指标，有助于早期识别重症或危重症患者。在这项横断面研究中，纳入了100名患者，并根据病情分为轻症组、重度组和危重症组。分析外周血炎症相关指标与病情危重度的相关性。通过ROC曲线推测危重患者的临界值。显着的是，疾病严重程度与年龄（R = -0.564，P < 0.001）、白细胞介素2受体（IL2R）（R = -0.534，P < 0.001）、白细胞介素6（IL-6）（R = -0.535， P < 0.001)、白细胞介素-8 (IL-8) (R = -0.308, P < 0.001)、白细胞介素 10 (IL-10) (R = -0.422, P < 0.001)、肿瘤坏死因子 α (TNFα) (R = -0.322，P < 0.001)，C反应蛋白(CRP) (R = -0.604，P < 0.001)，铁蛋白(R = -0.508，P < 0.001)，降钙素原(R = -0.650，P < 0.001)，白细胞计数 (WBC) (R = -0.54，P < 0.001)，淋巴细胞计数 (LC) (R = 0.56，P < 0.001)，中性粒细胞计数 (NC) （R = -0.585，P < 0.001）和嗜酸性粒细胞计数（EC）（R = 0.299，P < 0.001）。当IL2R> 793.5 U/mL或CRP> 30.7 ng/mL时，应密切观察并可能预防COVID-19进展到关键阶段。炎症与 COVID-19 的严重程度密切相关，IL-6 和 TNFα 可能是有希望的治疗靶点。
COVID-19 is highly contagious, and the crude mortality rate could reach 49% in critical patients. Inflammation concerns on disease progression. This study analyzed blood inflammation indicators among mild, severe and critical patients, helping to identify severe or critical patients early. In this cross-sectional study, 100 patients were included and divided into mild, severe or critical groups according to disease condition. Correlation of peripheral blood inflammation-related indicators with disease criticality was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve. Significantly, disease severity was associated with age (R = -0.564, P < 0.001), interleukin-2 receptor (IL2R) (R = -0.534, P < 0.001), interleukin-6 (IL-6) (R = -0.535, P < 0.001), interleukin-8 (IL-8) (R = -0.308, P < 0.001), interleukin-10 (IL-10) (R = -0.422, P < 0.001), tumor necrosis factor α (TNFα) (R = -0.322, P < 0.001), C-reactive protein (CRP) (R = -0.604, P < 0.001), ferroprotein (R = -0.508, P < 0.001), procalcitonin (R = -0.650, P < 0.001), white cell counts (WBC) (R = -0.54, P < 0.001), lymphocyte counts (LC) (R = 0.56, P < 0.001), neutrophil count (NC) (R = -0.585, P < 0.001) and eosinophil counts (EC) (R = 0.299, P < 0.001). With IL2R > 793.5 U/mL or CRP > 30.7 ng/mL, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Inflammation is closely related to severity of COVID-19, and IL-6 and TNFα might be promising therapeutic targets.
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