Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer.
Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer.
复制标题
DOI：
10.3390/biomedicines6020065
复制
发表时间：
2018-06-02
期刊：
影响因子：
4.7
通讯作者：
Harms JF
中科院分区：
文献类型：
--
作者：
Matters GL;Harms JF
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 74–75). There is an unmet need for reagents that can reliably identify early cancerous or precancerous lesions through various imaging modalities or could be employed to deliver anticancer treatments specifically to tumor cells. However, to date, many PDAC tumor-targeting strategies lack selectivity and are unable to discriminate between tumor and nontumor cells, causing off-target effects or unclear diagnoses. Although a variety of approaches have been taken to identify tumor-targeting reagents that can effectively direct therapeutics or imaging agents to cancer cells (Liu, D. et al., J. Controlled Release 2015, 219, 632–643), translating these reagents into clinical practice has been limited, and it remains an area open to new methodologies and reagents (O’Connor, J.P. et al., Nat. Rev. Clin. Oncol. 2017, 14, 169–186). G protein–coupled receptors (GPCRs), which are key target proteins for drug discovery and comprise a large proportion of currently marketed therapeutics, hold significant promise for tumor imaging and targeted treatment, particularly for pancreatic cancer.
登录
查看更多内容
CTLA-4拮抗DNA适体具有抗肿瘤作用。
DOI：
10.1016/j.omtn.2017.08.006
发表时间：
2017-09-15
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Huang BT;Lai WY;Chang YC;Wang JW;Yeh SD;Lin EP;Yang PC
通讯作者：
Yang PC
影响因子：
4.6
作者：
Hussain S;Rodriguez-Fernandez M;Braun GB;Doyle FJ 3rd;Ruoslahti E
通讯作者：
Ruoslahti E
DOI：
10.1016/j.ejpb.2017.06.027
发表时间：
2017-10-01
影响因子：
4.9
作者：
Bird, Joanna L.;Simpson, Rachael;Goddard, Alan D.
通讯作者：
Goddard, Alan D.
影响因子：
5.2
作者：
Hori SI;Herrera A;Rossi JJ;Zhou J
通讯作者：
Zhou J
影响因子：
17.1
作者：
Barth BM;Sharma R;Altinoğlu EI;Morgan TT;Shanmugavelandy SS;Kaiser JM;McGovern C;Matters GL;Smith JP;Kester M;Adair JH
通讯作者：
Adair JH