Dietary characteristics associated with plasma concentrations of per- and polyfluoroalkyl substances among adults with pre-diabetes: Cross-sectional results from the Diabetes Prevention Program Trial.
Dietary characteristics associated with plasma concentrations of per- and polyfluoroalkyl substances among adults with pre-diabetes: Cross-sectional results from the Diabetes Prevention Program Trial.
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DOI：
10.1016/j.envint.2019.105217
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发表时间：
2020-04
影响因子：
11.8
通讯作者：
Oken E
中科院分区：
文献类型：
--
作者：
Lin PD;Cardenas A;Hauser R;Gold DR;Kleinman KP;Hivert MF;Fleisch AF;Calafat AM;Sanchez-Guerra M;Osorio-Yáñez C;Webster TF;Horton ES;Oken E
在非职业暴露人群中，饮食被认为是全氟烷基和多氟烷基物质（PFAS）暴露的主要来源，但在美国，关于饮食与PFAS关系的研究很少。我们提取了多个饮食变量，包括食物组的每日摄入量、饮食评分和饮食模式，从基线（1996-1999年）收集的糖尿病前期成年人的自我报告饮食数据中提取，并使用线性回归模型评估每个饮食变量与血浆中六种PFAS(全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟己烷磺酸（PFHxS）、2-（n -乙基-全氟辛烷磺酰胺）乙酸（EtFOSAA）， 2-（n -甲基-全氟辛烷磺酰胺）乙酸（MeFOSAA），全氟壬烷酸（PFNA）调整协变量。参与者（N=941, 65%女性，58%白种人，68%已婚，75%受过高等教育，95%不吸烟者）在1999-2000年期间的PFAS浓度与美国总人口相似。采用单一食物组方法，炸鱼、其他鱼类/贝类、肉类和家禽与大多数PFAS血浆浓度呈正相关。检测到的最强效应估计是在煎鱼和PFNA之间[每SD增加中位浓度增加13.6% (95% CI: 7.7, 19.9)]。低碳水化合物高蛋白饮食评分与血浆PFHxS呈正相关。一些食物组，主要是蔬菜和水果，以及停止高血压的饮食方法评分与PFOS和MeFOSAA呈负相关。植物性饮食模式与较低的血浆MeFOSAA浓度相关，而高脂肪肉类、低纤维和高脂肪谷物饮食模式与较高的血浆PFOS、PFHxS、MeFOSAA和PFNA浓度相关。我们总结了与该人群中PFAS血浆浓度变化相关的四个主要饮食特征。具体来说，食用更多的肉/鱼/贝类（尤其是炸鱼，不包括富含Omega-3的鱼）、低纤维和高脂肪的面包/谷物/米饭/意大利面、咖啡/茶与较高的血浆浓度有关，而蔬菜、水果和富含Omega-3的鱼类的饮食模式与较低的血浆浓度有关。
Diet is assumed to be the main source of exposure to per- and polyfluoroalkyl substances (PFAS) in non-occupationally exposed populations, but studies on the diet-PFAS relationship in the United States are scarce. We extracted multiple dietary variables, including daily intakes of food group, diet scores, and dietary patterns, from self-reported dietary data collected at baseline (1996–1999) from adults with pre-diabetes enrolled in the Diabetes Prevention Program, and used linear regression models to evaluate relationships of each dietary variable with plasma concentrations of six PFAS (perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), 2-(N-ethyl-perfluorooctane sulfonamido) acetic acid (EtFOSAA), 2-(N-methyl-perfluorooctane sulfonamido) acetic acid (MeFOSAA), perfluorononanoic acid (PFNA) adjusting for covariates. Participants (N=941, 65% female, 58% Caucasian, 68% married, 75% with higher education, 95% nonsmoker) had similar PFAS concentrations compared to the general U.S. population during 1999–2000. Using a single food group approach, fried fish, other fish/shellfish, meat and poultry had positive associations with most PFAS plasma concentrations. The strongest effect estimate detected was between fried fish and PFNA [13.6% (95% CI: 7.7, 19.9) increase in median concentration per SD increase]. Low-carbohydrate and high protein diet score had positive association with plasma PFHxS. Some food groups, mostly vegetables and fruits, and the Dietary Approaches to Stop Hypertension diet score had inverse associations with PFOS and MeFOSAA. A vegetable diet pattern was associated with lower plasma concentrations of MeFOSAA, while high-fat meat and low-fiber and high-fat grains diet patterns were associated with higher plasma concentrations of PFOS, PFHxS, MeFOSAA and PFNA. We summarized four major dietary characteristics associated with variations in PFAS plasma concentrations in this population. Specifically, consuming more meat/fish/shellfish (especially fried fish, and excluding Omega3-rich fish), low-fiber and high-fat bread/cereal/rice/pasta, and coffee/tea was associated with higher plasma concentrations while dietary patterns of vegetables, fruits and Omega-3 rich fish were associated with lower plasma concentrations of some PFAS.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
5.8
作者：
Herzke, Dorte;Huber, Sandra;de Voogt, Pim
通讯作者：
de Voogt, Pim
影响因子：
8.8
作者：
Haug, Line Smastuen;Salihovic, Samira;Becher, Georg
通讯作者：
Becher, Georg
影响因子：
8.3
作者：
Christensen, Krista Y.;Raymond, Michelle;Turyk, Mary
通讯作者：
Turyk, Mary
影响因子：
1.7
作者：
Catelan, Dolores;Biggeri, Annibale
通讯作者：
Biggeri, Annibale