Apprehending multicellularity: regulatory networks, genomics, and evolution.
Apprehending multicellularity: regulatory networks, genomics, and evolution.
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DOI：
10.1002/bdrc.20153
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发表时间：
2009-06
影响因子：
--
通讯作者：
Venancio, Thiago M.
中科院分区：
文献类型：
--
作者：
Aravind, L.;Anantharaman, Vivek;Venancio, Thiago M.
基因组革命让我们第一次看到了调控网络的结构。结合进化信息，生命过程的“网络视图”导致对生物系统如何被各种力量塑造的显着见解。这种理解是至关重要的，因为生物系统，包括调控网络，不是工程的产物，而是历史偶然性的产物。在这种情况下，我们试图在多细胞生物体的发展和分化的自然历史的监管网络的综合概述。我们首先介绍监管网络和它们的组织原则，可以推导出使用图论的思想。然后，我们讨论了比较基因组学的研究结果，以说明谱系特异性扩增，基因丢失和非蛋白质编码DNA对网络结构的影响。我们认为转录因子的扩增之间的相互作用，顺式调节和更一般的染色质状态稳定元素的出现形态的复杂性。最后，我们考虑一个案例研究的缺口子网络，这是目前在整个后生动物，研究这样的监管系统已拼凑在一起，从新的创新和预先存在的组件，原来功能不同的演变。
The genomic revolution has provided the first glimpses of the architecture of regulatory networks. Combined with evolutionary information, the “network view” of life processes leads to remarkable insights into how biological systems have been shaped by various forces. This understanding is critical because biological systems, including regulatory networks, are not products of engineering but of historical contingencies. In this light, we attempt a synthetic overview of the natural history of regulatory networks operating in the development and differentiation of multicellular organisms. We first introduce regulatory networks and their organizational principles as can be deduced using ideas from the graph theory. We then discuss findings from comparative genomics to illustrate the effects of lineage-specific expansions, gene-loss, and non-protein-coding DNA on the architecture of networks. We consider the interaction between expansions of transcription factors, and cis regulatory and more general chromatin state stabilizing elements in the emergence of morphological complexity. Finally, we consider a case study of the Notch sub-network, which is present throughout Metazoa, to examine how such a regulatory system has been pieced together in evolution from new innovations and pre-existing components that were originally functionally distinct.
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影响因子：
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