Chemical Composition and Antifungal, Anti-Inflammatory, Antiviral, and Larvicidal Activities of the Essential Oils of Zanthoxylum acanthopodium DC. from China and Myanmar.
Chemical Composition and Antifungal, Anti-Inflammatory, Antiviral, and Larvicidal Activities of the Essential Oils of Zanthoxylum acanthopodium DC. from China and Myanmar.
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DOI：
10.3390/molecules27165243
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发表时间：
2022-08-17
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影响因子：
--
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刺花椒是一种广泛用于治疗发热、流感、胃痛、外伤和蚊虫叮咬的传统药用植物，在热带和亚热带亚洲。本研究旨在探讨其果实精油的抗真菌、抗炎、抗病毒及杀幼虫活性。中国样品（EOZC）主要由柠檬烯（29.78%）和β-月桂烯（26.65%）组成，缅甸样品（EOZM）主要由松油烯-4-醇（43.35%）组成。两种精油均显示出抗真菌活性，90%最小抑菌浓度（MIC 90）值范围为26.3至499 μg/mL。EOZC（IC 50，16 μg/mL）对RAW 264.7细胞的一氧化氮（NO）有明显的抑制作用，其抗炎活性与阳性对照L-NMMA（IC 50，12.2 μg/mL）相当。EOZM对登革病毒具有明显的抗病毒活性，IC 50值为13 μg/mL。此外，EOZC和EOZM均表现出对白纹伊蚊的剂量依赖性杀幼虫活性，LC 50和LC 90值范围为45.8 - 144.0 μg/mL。研究结果为花椒的进一步开发利用提供了理论依据。作为制药工业中的抗真菌和抗炎成分，并进一步表明其具有开发为用于预防和治疗登革热病毒的天然和生态友好药物的新来源的潜力。
Zanthoxylum acanthopodium DC. is a widely used traditional medicinal plant to treat fever, flu, stomachache, traumatic injury, and mosquito bite in tropical and subtropical Asia. This study aimed to investigate the antifungal, anti-inflammatory, antiviral, and larvicidal activities of its fruit essential oil. The essential oil sample from China (EOZC) was mainly composed of limonene (29.78%) and β-myrcene (26.65%), while the sample from Myanmar (EOZM) was dominated by Terpinen-4-ol (43.35%). Both essential oils showed antifungal activity, with 90% minimum inhibitory concentration (MIC90) values ranging from 26.3 to 499 μg/mL. By obviously inhibiting nitric oxide (NO) in RAW 264.7 cells, EOZC (IC50, 16 μg/mL) showed comparable anti-inflammatory activity to the positive control L-NMMA (IC50, 12.2 μg/mL). EOZM showed significant antiviral activity against the dengue virus with an IC50 value of 13 μg/mL. Additionally, both EOZC and EOZM demonstrated dose-dependent larvicidal activity against Aedes albopictus, with LC50 and LC90 values ranging from 45.8 to 144.0 μg/mL. Our results contribute a theoretical foundation for the further application of Zanthoxylum acanthopodium DC. as an antifungal and anti-inflammatory ingredient in the pharmaceutical industry and further indicate that it has the potential to be developed as a new source of natural and eco-friendly medicine for the prevention and treatment of dengue virus.
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DOI：
10.1016/s1473-3099(16)30545-x
发表时间：
2017-03-01
期刊：
The Lancet. Infectious diseases
影响因子：
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