Dietary syringic acid reduces fat mass in an ovariectomy-induced mouse model of obesity
Dietary syringic acid reduces fat mass in an ovariectomy-induced mouse model of obesity
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膳食丁香酸可减少卵巢切除诱导的肥胖小鼠模型中的脂肪量
DOI：
10.1097/gme.0000000000001853
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发表时间：
2021
期刊：
影响因子：
2.7
通讯作者：
Yoshimi Homma
中科院分区：
文献类型：
--
作者：
Teruyoshi Tanaka;Kazuko Iwamoto;Maki Wada;Erika Yano;Toshiyuki Suzuki;Nobuhisa Kawaguchi;Norifumi Shirasaka;Tatsuya Moriyama;Yoshimi Homma
目的：绝经后妇女患肥胖和糖尿病等代谢性疾病的风险增加。因此，通过膳食补充剂化学预防绝经后健康变化是重要的。丁香酸（Syringic acid，SA）是一种酚类化合物，存在于阿赛棕榈（Euterpe oleracea）的果实和香菇（Lentinula edodes）的菌丝体中。该化合物对雌激素受体没有亲和力，可能具有疾病预防作用。据报道，饮食SA改善高脂饮食诱导的小鼠肥胖;然而，其对雌激素缺乏诱导的肥胖的影响尚不清楚。因此，在这项研究中，我们调查饮食SA是否以及如何影响这些因素在卵巢切除（OVX）mice.Methods：10周龄OVX小鼠饲喂含SA的饮食（100 mg/kg体重/d）12周。结果：在整个研究期间，SA饮食对OVX小鼠的体重、摄食量和子宫重量没有影响，但SA饮食组的脂肪量较对照组低（即内脏，皮下和总脂肪）比OVX对照组（11.1±3.3 vs. 8.3±2.4，P< 0.05; 7.9±1.1 vs. 5.9±1.6，P< 0.05; 19.0±4.2 vs. 14.1±3.8，P< 0.05）。此外，血液分析显示，SA处理导致血清甘油三酯（59.2±8.3 vs.43.9 ±12.2 mg/dL P< 0.05）和脂联素（7.7±0.3 vs.9.5 ±0.6 μg/mL，P< 0.05）水平分别呈剂量依赖性降低和升高。因此，膳食SA对预防绝经后肥胖和2型糖尿病具有潜在的适用性。
Objective:Postmenopausal women are at increased risk of metabolic diseases such as obesity and diabetes. Therefore, the chemoprevention of postmenopausal changes in health via dietary supplements is important. Syringic acid (SA) is a phenolic compound present in the fruit of the assai palm, Euterpe oleracea, and in the mycelium of the shiitake mushroom, Lentinula edodes. This compound shows no affinity for estrogen receptors and may exert disease-preventive effects. Reportedly, dietary SA ameliorates high-fat diet-induced obesity in mice; however, its effects on estrogen deficiency-induced obesity are still unclear. Therefore, in this study, we investigated whether and how dietary SA affects these factors in ovariectomized (OVX) mice.Methods:Ten-week-old OVX mice were fed SA-containing diets (100 mg/kg body weight/d) for 12 weeks. Their body weights, food intake, and uterus weights as well as other parameters were measured and comparisons were made with mice in the control group.Results:Dietary SA did not affect the body weight, food intake, or uterus weight of OVX mice over the study period; however, the SA-fed group showed lower fat mass (ie, visceral, subcutaneous, and total fat) than the OVX-control group (11.1±3.3 vs. 8.3±2.4, P< 0.05; 7.9±1.1 vs. 5.9±1.6, P< 0.05; 19.0±4.2 vs. 14.1±3.8, P< 0.05, respectively). Furthermore, blood analysis revealed that SA-treatment resulted in a dose-dependent decrease and increase in serum triglyceride (59.2±8.3 vs. 43.9±12.2 mg/dL P< 0.05) and adiponectin (7.7±0.3 vs. 9.5±0.6 μg/mL, P< 0.05) levels, respectively.Conclusions:These results suggest that the SA diet improves lipid metabolism without affecting the uterus in OVX mice. Therefore, dietary SA has potential applicability for the prevention of postmenopausal obesity and type 2 diabetes.
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影响因子：
8.7
作者：
Hotta, K;Funahashi, T;Matsuzawa, Y
通讯作者：
Matsuzawa, Y
影响因子：
2.2
作者：
John, Cordelia Mano;Arockiasamy, Sumathy
通讯作者：
Arockiasamy, Sumathy
雌激素拮抗剂 EM-652 和脱氢表雄酮可预防饮食和卵巢切除引起的肥胖。
DOI：
--
发表时间：
2003
期刊：
Obesity Research
影响因子：
--
作者：
C. Lemieux;F. Picard;F. Labrie;D. Richard;Y. Deshaies
通讯作者：
Y. Deshaies
影响因子：
5
作者：
Ohtomo, Takuya;Uehara, Mariko;Ishimi, Yoshiko
通讯作者：
Ishimi, Yoshiko
影响因子：
2
作者：
Itoh, Ayano;Isoda, Katsuhiro;Yagi, Kiyohito
通讯作者：
Yagi, Kiyohito