Neuropsychological and neuroimaging markers in early versus late-onset Alzheimer's disease.
Neuropsychological and neuroimaging markers in early versus late-onset Alzheimer's disease.
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DOI：
10.1177/1533317512459798
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Mendez MF
中科院分区：
文献类型：
--
作者：
Kaiser NC;Melrose RJ;Liu C;Sultzer DL;Jimenez E;Su M;Monserratt L;Mendez MF
Early-onset Alzheimer’s disease (EOAD) has been overshadowed by the more common late-onset AD (LOAD). Yet, the literature indicates EOAD may have less hippocampal-memory presentations and more focal neocortical localization early in the disease. To evaluate these proposed differences between these two forms of AD and to explore what they inform about differences in AD-pathophysiology. 21 EOAD and 24 LOAD patients matched for disease progression and severity were compared on neurocognitive measures and resting state fluorodeoxy-glucose positron emission tomography (FDG-PET). EOAD patients had worse executive functions with greater hypometabolism in the parietal regions; whereas LOAD patients had worse confrontation naming and verbal recognition memory with greater hypometabolism in inferior frontotemporal regions. In addition to highlighting significant differences between EOAD and LOAD, these results reveal dissociation between executive deficits in AD and frontal hypometabolism, suggesting early disturbances of the parietal-frontal network in EOAD.
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影响因子：
--
作者：
Reid, W;Broe, G;Sulway, MR
通讯作者：
Sulway, MR
影响因子：
11
作者：
Frisoni, GB;Testa, C;Laakso, MP
通讯作者：
Laakso, MP
DOI：
10.1177/1533317506299156
发表时间：
2007-06-01
期刊：
American journal of Alzheimer's disease and other dementias
影响因子：
--
作者：
Licht, Eliot A;McMurtray, Aaron M;Mendez, Mario F
通讯作者：
Mendez, Mario F
DOI：
10.1097/01.wnn.0000119564.08162.46
发表时间：
2004-06-01
期刊：
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
影响因子：
--
作者：
Cosentino, Stephanie;Jefferson, Angela;Libon, David J
通讯作者：
Libon, David J
DOI：
10.1159/000107340
发表时间：
1993-11-01
期刊：
DEMENTIA
影响因子：
--
作者：
BINETTI, G;MAGNI, E;TRABUCCHI, M
通讯作者：
TRABUCCHI, M