Uterine leiomyomata in a cohort of Great Lakes sport fish consumers.
Uterine leiomyomata in a cohort of Great Lakes sport fish consumers.
复制标题
DOI：
10.1016/j.envres.2011.01.006
复制
发表时间：
2011-05
影响因子：
8.3
通讯作者：
Persky V
中科院分区：
文献类型：
--
作者：
Lambertino A;Turyk M;Anderson H;Freels S;Persky V
饮食和内分泌干扰持久性有机污染物（POP）与妇科疾病有关，包括子宫平滑肌瘤（UL），子宫内膜异位症和卵巢囊肿。五大湖的观赏鱼消费是接触持久性有机污染物的一个来源，如p，p '-二苯基二氯乙烯（DDE）和多氯联苯（PCB）。本研究的目的是回顾性研究的影响五大湖运动鱼类消费的UL的发病率，并检查DDE和PCB血清水平的影响普遍UL的妇女参加了五大湖鱼类消费研究。我们假设暴露与UL的关联会被母乳喂养状态所改变。通过调查评估了运动鱼类消费、人口、健康和生殖数据的年数。在一个亚组中，收集血清并检测DDE和PCB水平。使用时间依赖性考克斯比例风险回归和持久性有机污染物暴露对UL的影响进行建模的影响，多年的五大湖运动鱼和运动鱼消费。运动鱼类消费的年数与UL相关，鱼类消费每增加10年，发病率比为1.2（95%CI 1.0-1.3）。总体组中持久性有机污染物暴露的汇总测量与UL无关。然而，在从未母乳喂养的妇女亚组中，可获得PCB测量结果，UL与PCB以及雌激素、抗雌激素和二恶英类PCB分组显著相关。这些发现支持了食用鱼类导致的多氯联苯暴露可能会增加UL风险的可能性，并强调了探索其可能作用的生物途径的额外研究的重要性。
Diet and endocrine disrupting persistent organic pollutants (POPs) have been associated with gynecologic conditions including uterine leiomyomata (UL), endometriosis, and ovarian cysts. Great Lakes sport fish consumption is a source of exposure to POPs such as p,p’-diphenyldichloroethene (DDE) and polychlorinated biphenyls (PCBs). This study was designed to examine retrospectively the effects Great Lakes sport fish consumption on the incidence of UL and to examine the effects of DDE and PCB serum levels on prevalent UL in women participating in the Great Lakes Fish Consumption Study. We hypothesized that associations of exposures with UL would be modified by breastfeeding status. Years of sport fish consumption, demographic, health, and reproductive data were assessed by survey. In a subgroup, serum was collected and tested for DDE and PCB levels. Effects of years of Great Lakes sport fish and sport fish consumption were modeled using time-dependent Cox proportional hazards regression and effects of POP exposures on UL were modeled using multiple logistic regression. Years of sport fish consumption were associated with UL, with an incidence rate ratio of 1.2 (95% CI 1.0-1.3) for each 10-year increment of fish consumption. Summary measures of POP exposures in the overall group were not associated with UL. In the subgroup of women who never breastfed and in whom PCB measurements were available, however, UL was significantly associated with PCBs and groupings of estrogenic, antiestrogenic, and dioxin-like PCBs. These findings support the possibility that PCB exposures from fish consumption may increase the risk of UL and highlight the importance of additional studies exploring biologic pathways by which they could be acting.
登录
查看更多内容
影响因子：
7.2
作者：
Farquhar, CM;Steiner, CA
通讯作者：
Steiner, CA
影响因子：
6
作者：
Calder, Philip C.;Yaqoob, Parveen
通讯作者：
Yaqoob, Parveen
影响因子：
2.5
作者：
BURSE, VW;HEAD, SL;NEEDHAM, LL
通讯作者：
NEEDHAM, LL
影响因子：
7.2
作者：
Chiaffarino, F;Parazzini, F;Marsico, S
通讯作者：
Marsico, S
影响因子：
10.4
作者：
Hunter, DS;Hodges, LC;Walker, CL
通讯作者：
Walker, CL