Diagnosis and biomarkers of predementia in Alzheimer's disease.
Diagnosis and biomarkers of predementia in Alzheimer's disease.
复制标题
DOI：
10.1186/1741-7015-8-89
复制
发表时间：
2010-12-22
期刊：
影响因子：
9.3
通讯作者：
Gattaz WF
中科院分区：
文献类型：
--
作者：
Forlenza OV;Diniz BS;Gattaz WF
鉴于阿尔茨海默病（AD）在全球范围内的日益流行，迫切需要开发更好的诊断工具和更有效的治疗干预措施。在AD的最早阶段，通过常规临床方法未检测到显著的认知或功能障碍。然而，新技术的基础上结构和功能的神经影像学，并对脑脊液（CSF）的生化分析可能会揭示相关的脑内病理在个人轻度，痴呆前症状。这些推定的相关性通常被称为AD相关生物标志物。AD早期诊断的相关性依赖于以下假设：如果在痴呆的连续过程中足够早地开始，则使用疾病改善化合物的药理学干预可能产生临床相关益处。在这里，我们回顾了AD患者从正常认知老化到痴呆的前驱期和过渡期的临床特征。我们进一步讨论了生物标志物研究的最新进展，以支持痴呆症的早期诊断和预测，并指出了将研究数据转化为临床实践的挑战和前景。
In view of the growing prevalence of Alzheimer's disease (AD) worldwide, there is an urgent need for the development of better diagnostic tools and more effective therapeutic interventions. At the earliest stages of AD, no significant cognitive or functional impairment is detected by conventional clinical methods. However, new technologies based on structural and functional neuroimaging, and on the biochemical analysis of cerebrospinal fluid (CSF) may reveal correlates of intracerebral pathology in individuals with mild, predementia symptoms. These putative correlates are commonly referred to as AD-related biomarkers. The relevance of the early diagnosis of AD relies on the hypothesis that pharmacological interventions with disease-modifying compounds are likely to produce clinically relevant benefits if started early enough in the continuum towards dementia. Here we review the clinical characteristics of the prodromal and transitional states from normal cognitive ageing to dementia in AD. We further address recent developments in biomarker research to support the early diagnosis and prediction of dementia, and point out the challenges and perspectives for the translation of research data into clinical practice.
登录
查看更多内容
影响因子：
--
作者：
Abreu, Izabella Dutra de;Nunes, Paula Villela;Forlenza, Orestes Vicente
通讯作者：
Forlenza, Orestes Vicente
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
0.8
作者：
Chételat, G;Eustache, F;Desgranges, B
通讯作者：
Desgranges, B
影响因子：
9.9
作者：
Busse, A.;Hensel, A.;Riedel-Heller, S. G.
通讯作者：
Riedel-Heller, S. G.
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.