The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: A case report
The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: A case report
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体动记录仪、日记数据和尿褪黑激素谱对精神分裂症睡眠障碍定量评估的适用性：病例报告
DOI：
10.1080/07420520500545987
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发表时间：
2006
影响因子：
2.8
通讯作者：
R. Foster
中科院分区：
文献类型：
--
作者：
K. Wulff;E. Joyce;B. Middleton;D. Dijk;R. Foster
睡眠中断是精神分裂症患者常见的临床特征，其中一个重要的问题是确定这种中断在“真实的”生活情况下的程度。同时进行手腕体动记录、日记记录和重复尿液收集以获得尿液6-硫酸氧褪黑激素（aMT 6）曲线是在现场研究中评估昼夜节律和睡眠模式的适当工具。他们是否适合长期记录生活在社区的精神分裂症患者尚未进行评估。在这份病例报告中，我们记录了长期同时进行的腕动记录、光检测、重复尿液收集和日记记录，作为非侵入性技术的适当组合，以量化和评估精神分裂症患者睡眠-觉醒周期、光照和褪黑激素分布的变化。患者对活动记录仪的耐受性良好，在家庭成员的帮助下，对日记记录和48小时尿液采集的依从性特别好。通过这些技术获得的数据进行了说明，结果揭示了休息活动模式，光照和褪黑激素产生的显着异常模式。我们观察到各种休息-活动模式，包括相移，高度延迟的睡眠和偏移，以及不规则的休息-活动阶段。静息-活动节律、光暗周期和褪黑激素节律的周期均长于24 h。这些昼夜节律的异常可能会加强睡眠模式的改变，以及与精神分裂症相关的认知功能和社会参与问题。
Sleep disruption is a commonly encountered clinical feature in schizophrenic patients, and one important concern is to determine the extent of this disruption under “real” life situations. Simultaneous wrist actigraphy, diary records, and repeated urine collection for urinary 6‐sulphatoxymelatonin (aMT6s) profiles are appropriate tools to assess circadian rhythms and sleep patterns in field studies. Their suitability for long‐term recordings of schizophrenic patients living in the community has not been evaluated. In this case report, we document long‐term simultaneous wrist actigraphy, light detection, repeated urine collection, and diary records as a suitable combination of non‐invasive techniques to quantify and assess changes in sleep‐wake cycles, light exposure, and melatonin profiles in a schizophrenic patient. The actigraph was well‐tolerated by the patient, and compliance to diary records and 48 h urine collection was particularly good with assistance from family members. The data obtained by these techniques are illustrated, and the results reveal remarkable abnormal patterns of rest‐activity patterns, light exposure, and melatonin production. We observed various rest‐activity patterns, including phase‐shifts, highly delayed sleep on‐ and offsets, and irregular rest‐activity phases. The period of the rest‐activity rhythm, light‐dark cycle, and melatonin rhythm was longer than 24 h. These circadian abnormalities may reinforce the altered sleep patterns and the problems of cognitive function and social engagement associated with schizophrenic.
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影响因子：
2.8
作者：
LEWY, AJ;SACK, RL
通讯作者：
SACK, RL
使用褪黑激素治疗睡眠和昼夜节律紊乱。
影响因子：
4.4
作者：
Sack,RL;Lewy,AJ;Hughes,RJ
通讯作者：
Hughes,RJ
影响因子：
6.6
作者：
Kripke, DF
通讯作者：
Kripke, DF
影响因子：
--
作者：
Eastman, CI;Young, MA;Meaden, PM
通讯作者：
Meaden, PM