Sex disparities in influenza: A multiscale network analysis.
Sex disparities in influenza: A multiscale network analysis.
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DOI：
10.1016/j.isci.2022.104192
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发表时间：
2022-05-20
期刊：
影响因子：
5.8
通讯作者：
Forst, Christian V.
中科院分区：
文献类型：
--
作者：
Wang, Chang;Lashua, Lauren P.;Carter, Chalise E.;Johnson, Scott K.;Wang, Minghui;Ross, Ted M.;Ghedin, Elodie;Zhang, Bin;Forst, Christian V.
对于多种病原体，由于女性和男性之间的不同免疫反应，传染病发病机制的性别差异已得到充分证明。然而，在流感病毒感染中观察到的性别差异的分子机制仍然知之甚少。在这项研究中，我们使用了一种基于网络的方法来表征在感染A型流感病毒的过程中从雌性和雄性雪貂收集的血液转录组，以剖析性别偏见的基因表达。我们确定了显着差异的时间动态和调节的免疫反应之间的女性和男性。我们的研究结果阐明了参与未折叠蛋白反应（UPR），脂质代谢和炎症反应的性别分化途径，包括代谢重编程与IL-1和AP-1途径之间的女性偏见IRE 1/XBP 1激活和男性偏见串扰。总的来说，我们的研究提供了免疫反应转录调节的性别差异的分子见解，并有助于更好地了解流感发病机制中的性别偏见。雌性和雄性之间的免疫反应调节存在显著差异雌性中UPR的快速激活触发了有效的免疫和炎症反应AP 1通路中的雄性特异性调节模式表明免疫反应存在偏倚生物科学;免疫学;病毒学;系统生物学
Sex differences in the pathogenesis of infectious diseases because of differential immune responses between females and males have been well-documented for multiple pathogens. However, the molecular mechanism underlying the observed sex differences in influenza virus infection remains poorly understood. In this study, we used a network-based approach to characterize the blood transcriptome collected over the course of infection with influenza A virus from female and male ferrets to dissect sex-biased gene expression. We identified significant differences in the temporal dynamics and regulation of immune responses between females and males. Our results elucidate sex-differentiated pathways involved in the unfolded protein response (UPR), lipid metabolism, and inflammatory responses, including a female-biased IRE1/XBP1 activation and male-biased crosstalk between metabolic reprogramming and IL-1 and AP-1 pathways. Overall, our study provides molecular insights into sex differences in transcriptional regulation of immune responses and contributes to a better understanding of sex biases in influenza pathogenesis. Regulation of immune responses between females and males is significantly different Rapid activation of UPR in females triggers potent immune and inflammatory responses Male-specific regulatory pattern in the AP1 pathway indicate a bias in immune response Biological sciences; Immunology; Virology; Systems biology
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DOI：
10.1038/nri2394
发表时间：
2008-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Fish EN
通讯作者：
Fish EN
癌症死亡率和生存中的性别差异。
DOI：
10.1158/1055-9965.epi-11-0246
发表时间：
2011-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cook MB;McGlynn KA;Devesa SS;Freedman ND;Anderson WF
通讯作者：
Anderson WF
影响因子：
7.8
作者：
Giefing-Kröll C;Berger P;Lepperdinger G;Grubeck-Loebenstein B
通讯作者：
Grubeck-Loebenstein B
DOI：
10.1073/pnas.1805268115
发表时间：
2018-12-04
影响因子：
11.1
作者：
Fink, Ashley L.;Engle, Kyrra;Klein, Sabra L.
通讯作者：
Klein, Sabra L.
影响因子：
6
作者：
Bissel, Stephanie J.;Carter, Chalise E.;Ross, Ted M.
通讯作者：
Ross, Ted M.