Mismatch negativity and p3a/reorienting complex in subjects with schizophrenia or at-risk mental state.
Mismatch negativity and p3a/reorienting complex in subjects with schizophrenia or at-risk mental state.
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精神分裂症或高危心理状态的受试者中的不匹配的负效率和P3A/重新定位复合物。
DOI：
10.3389/fnbeh.2014.00172
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发表时间：
2014
影响因子：
3
通讯作者：
Sumiyoshi T
中科院分区：
文献类型：
--
作者：
Higuchi Y;Seo T;Miyanishi T;Kawasaki Y;Suzuki M;Sumiyoshi T
简介：我们测量了高危精神状态 (ARMS) 受试者、首发或慢性精神分裂症患者以及健康志愿者的持续时间失配负性 (dMMN)、P3a 和重新定向负性 (RON)。主要兴趣是确定这些事件相关电位是否提供与 ARMS 受试者进展为明显精神分裂症相关的生物标志物。方法：符合ARMS综合评估标准的19名ARMS受试者、38名精神分裂症患者（首发19名、慢性19名）和19名健康对照者参与研究。 dMMN、P3a 和 RON 在基线时使用听觉奇怪范式进行测量。结果：在随访期间（2.2 年），19 名 ARMS 受试者中有 4 名转变为精神分裂症（转变者），而 15 人则没有转变为精神分裂症（非转变者）。发病前，转换者的额部和中央电极的 dMMN 振幅明显小于非转换者。非转化者的 dMMN 振幅与健康对照者没有差异，而转化者与对照受试者相比，显示出明显更小的 dMMN 振幅。精神分裂症患者的额叶和中央电极处的 RON 振幅也有所降低，但 ARMS 则没有。与非皈依者相比，皈依者倾向于表现出较小的 RON 幅度。结论：我们的数据证实，dMMN 振幅减小提供了一种生物标志物，该生物标志物在精神病发生之前和之后都存在。在这方面，RON 振幅也可能有用，正如根据纵向观测首次建议的那样。
Introduction: We measured duration mismatch negativity (dMMN), P3a, and reorienting negativity (RON) in subjects with at-risk mental state (ARMS), patients with first-episode or chronic schizophrenia, and healthy volunteers. The main interest was to determine if these event-related potentials provide a biomarker associated with progression to overt schizophrenia in ARMS subjects. Methods: Nineteen ARMS subjects meeting the criteria of the Comprehensive Assessment of ARMS, 38 patients with schizophrenia (19 first-episode and 19 chronic), and 19 healthy controls participated in the study. dMMN, P3a, and RON were measured with an auditory odd-ball paradigm at baseline. Results: During the follow-up period (2.2 years), 4 out of the 19 ARMS subjects transitioned to schizophrenia (Converters) while 15 did not (non-Converters). dMMN amplitudes of Converters were significantly smaller than those of non-Converters at frontal and central electrodes before onset of illness. dMMN amplitudes of non-Converters did not differ from those of healthy controls, while Converters showed significantly smaller dMMN amplitudes compared to control subjects. RON amplitudes were also reduced at frontal and central electrodes in subjects with schizophrenia, but not ARMS. Converter subjects tended to show smaller RON amplitudes compared to non-Converters. Conclusions: Our data confirm that diminished dMMN amplitudes provide a biomarker, which is present before and after the development of psychosis. In this respect, RON amplitudes may also be useful, as suggested for the first time based on longitudinal observations.
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影响因子：
3.7
作者：
Higuchi Y;Sumiyoshi T;Seo T;Miyanishi T;Kawasaki Y;Suzuki M
通讯作者：
Suzuki M
影响因子：
4.7
作者：
Kasai, K;Yamada, H;Kato, N
通讯作者：
Kato, N
影响因子：
4.5
作者：
Higuchi, Yuko;Sumiyoshi, Tomiki;Kurachi, Masayoshi
通讯作者：
Kurachi, Masayoshi
影响因子：
3.7
作者：
Lin YT;Liu CM;Chiu MJ;Liu CC;Chien YL;Hwang TJ;Jaw FS;Shan JC;Hsieh MH;Hwu HG
通讯作者：
Hwu HG
影响因子：
5.7
作者：
Kawasaki, Yasuhiro;Suzuki, Michio;Kurachi, Masayoshi
通讯作者：
Kurachi, Masayoshi