Mismatch negativity and cognitive performance for the prediction of psychosis in subjects with at-risk mental state.
Mismatch negativity and cognitive performance for the prediction of psychosis in subjects with at-risk mental state.
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DOI：
10.1371/journal.pone.0054080
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Suzuki M
中科院分区：
文献类型：
--
作者：
Higuchi Y;Sumiyoshi T;Seo T;Miyanishi T;Kawasaki Y;Suzuki M
精神分裂症患者未经治疗的精神病持续时间越短，预后越好。在这项研究中，我们测量了持续时间不匹配负波（dMMN），事件相关电位，和认知表现的受试者与危险的精神状态（ARMS），首发或慢性精神分裂症患者，健康志愿者。主要目的是确定这些神经认知指标是否能预测ARMS受试者进展为显性精神分裂症。17名符合高危精神状态综合评定标准的ARMS受试者、31名精神分裂症患者（首发20例、慢性11例）和20名健康对照者参加了研究。 在基线时通过听觉奇球范式测量dMMN。采用日本版精神分裂症认知功能简易评定量表（BACS-J）评价神经心理学表现。首次发病的精神分裂症组表现出显着较小的幅度在额叶电极比对照组，而慢性患者引起较小的幅度在额叶和中央电极，与以前的报告一致。在随访期间，17例ARMS受试者中有4例转变为精神分裂症（转换者），而13例未转变为精神分裂症（非转换者）。具体而言，非转换者的dMMN振幅与健康对照者的dMMN振幅没有差异，而与对照受试者相比，转换者在某些电极处显示出显著较小的dMMN振幅。转换者在工作记忆、语言流畅性和注意力/信息处理测试中的表现明显不如非转换者。有一个显着的正相关性dMMN振幅在额叶电极和言语流畅性，作为衡量的BACS，在AMRS科目作为一个整体。与非转换者相比，后来发展为精神分裂症的ARMS受试者在开始时引起的dMMN振幅较小。值得注意的是，我们提供了第一个证据的能力，言语流畅性预测dMMN幅度在ARMS科目。这些发现有望为精神分裂症的早期诊断和干预做出贡献。
A shorter duration of untreated psychosis has been associated with better prognosis in schizophrenia. In this study, we measured the duration mismatch negativity (dMMN), an event-related potential, and cognitive performance in subjects with at-risk mental state (ARMS), patients with first-episode or chronic schizophrenia, and healthy volunteers. The main interest was to determine if these neurocognitive measures predict progression to overt schizophrenia in ARMS subjects. Seventeen ARMS subjects, meeting the criteria of the Comprehensive Assessment of At-Risk Mental State, 31 schizophrenia patients (20 first-episode and 11 chronic) and healthy controls (N = 20) participated in the study. dMMN was measured by an auditory odd-ball paradigm at baseline. Neuropsychological performance was evaluated by the Japanese version of the Brief assessment of cognitive function of schizophrenia (BACS-J). The first-episode schizophrenia group showed significantly smaller amplitudes at frontal electrodes than did control subjects whereas chronic patients elicited smaller amplitudes at frontal and central electrodes, consistent with previous reports. During the follow-up period, 4 out of the 17 ARMS subjects transitioned to schizophrenia (converters) while 13 did not (non-converters). Specifically, dMMN amplitudes of non-converters did not differ from those of healthy controls, while converters showed significantly smaller dMMN amplitudes at some electrodes compared to control subjects. Converters performed significantly worse on tests of working memory, verbal fluency, and attention/information processing than did non-converters. There was a significant positive correlation between dMMN amplitudes at the frontal electrodes and verbal fluency, as measured by the BACS, in the AMRS subjects as a whole. ARMS subjects who later developed schizophrenia elicited smaller dMMN amplitudes to begin with, compared to non-converters. Notably, we have provided the first evidence for the ability of verbal fluency to predict dMMN amplitudes in ARMS subjects. These findings are expected to add to the efforts for early diagnosis and intervention of schizophrenia.
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DOI：
10.1176/appi.ajp.2011.10081209
发表时间：
2011-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Carrión RE;Goldberg TE;McLaughlin D;Auther AM;Correll CU;Cornblatt BA
通讯作者：
Cornblatt BA
影响因子：
1.6
作者：
Eriksson, J;Villa, AEP
通讯作者：
Villa, AEP
影响因子：
4.5
作者：
Higuchi, Yuko;Sumiyoshi, Tomiki;Kurachi, Masayoshi
通讯作者：
Kurachi, Masayoshi
影响因子：
4.7
作者：
Kasai, K;Yamada, H;Kato, N
通讯作者：
Kato, N
影响因子：
5.7
作者：
Kawasaki, Yasuhiro;Suzuki, Michio;Kurachi, Masayoshi
通讯作者：
Kurachi, Masayoshi