Biobehavioral Markers of Attention Bias Modification in Temperamental Risk for Anxiety: A Randomized Control Trial.
Biobehavioral Markers of Attention Bias Modification in Temperamental Risk for Anxiety: A Randomized Control Trial.
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DOI：
10.1016/j.jaac.2017.11.016
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发表时间：
2018-03
影响因子：
13.3
通讯作者：
Pérez-Edgar KE
中科院分区：
文献类型：
--
作者：
Liu P;Taber-Thomas BC;Fu X;Pérez-Edgar KE
Children with behavioral inhibition, a temperament characterized by biologically based hypervigilance to novelty and social withdrawal, are at high risk for developing anxiety. This study examined the effect of a novel attention training protocol, attention bias modification (ABM), on symptomatic, behavioral, and neural risk markers in children with behavioral inhibition. Nine- to 12-year-old typically developing children identified as having behavioral inhibition (N = 84) were assigned to a 4-session active ABM training (n = 43) or placebo protocol (n = 41) using a double-blinded, randomized, controlled trial approach. Anxiety symptoms (Diagnostic Interview Schedule for Children–Fourth Edition), attention bias (AB; measured by a dot-probe task; AB = incongruent reaction time – congruent reaction time), and AB-related neural activation (measured by functional magnetic resonance imaging activation for the incongruent > congruent contrast in the dot-probe task) were assessed before and after the training sessions. Results showed that active ABM (n = 40) significantly alleviated participants’ symptoms of separation anxiety, but not social anxiety, compared with the placebo task (n = 40); ABM did not modify behavioral AB scores in the dot-probe task; and at the neural level, active ABM (n = 15) significantly decreased amygdala and insula activation and increased activation in the ventrolateral prefrontal cortex compared with placebo (n = 19). These findings provide important evidence for ABM as a potentially effective protective tool for temperamentally at-risk children in a developmental window before the emergence of clinical disorder and open to prevention and intervention. Attention and Social Behavior in Children (BRAINS); https://clinicaltrials.gov/; NCT02401282.
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DOI：
10.1097/chi.0b013e3181ae09df
发表时间：
2009-09
影响因子：
13.3
作者：
Chronis-Tuscano A;Degnan KA;Pine DS;Perez-Edgar K;Henderson HA;Diaz Y;Raggi VL;Fox NA
通讯作者：
Fox NA
影响因子：
4.7
作者：
Britton, Jennifer C.;Bar-Haim, Yair;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
4.1
作者：
Ferdinand, Robert F.;Bongers, Ilja L.;Verhulst, Frank C.
通讯作者：
Verhulst, Frank C.
影响因子：
10.6
作者：
Browning, Michael;Holmes, Emily A.;Harmer, Catherine J.
通讯作者：
Harmer, Catherine J.
影响因子：
4.6
作者：
Bishop, G;Spence, SH;McDonald, C
通讯作者：
McDonald, C