Quercitrin protects skin from UVB-induced oxidative damage.
Quercitrin protects skin from UVB-induced oxidative damage.
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DOI：
10.1016/j.taap.2013.03.015
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发表时间：
2013-06-01
影响因子：
3.8
通讯作者：
Zhang, Zhuo
中科院分区：
文献类型：
--
作者：
Yin, Yuanqin;Li, Wenqi;Son, Young-Ok;Sun, Lijuan;Lu, Jian;Kim, Donghern;Wang, Xin;Yao, Hua;Wang, Lei;Pratheeshkumar, Poyil;Hitron, Andrew J.;Luo, Jia;Gao, Ning;Shi, Xianglin;Zhang, Zhuo
皮肤暴露于紫外线B（UVB）辐射会对皮肤造成氧化损伤，导致晒伤、光老化和皮肤癌。一般认为，紫外线照射引起的皮肤损伤是活性氧（ROS）产生的结果。最近，由于天然产物的抗氧化剂和抗炎特性，人们对使用天然产物作为非黑色素瘤皮肤癌（NMSC）的化学预防剂越来越感兴趣。槲皮苷是槲皮素的糖基化形式，是自然界中最常见的具有抗氧化特性的黄酮类化合物。本研究探讨了槲皮苷在体外和体内抑制UVB辐射诱导的氧化损伤的可能有益作用。我们的结果表明，槲皮苷减少UVB照射诱导的JB 6细胞ROS的产生。槲皮苷恢复过氧化氢酶的表达和GSH/GSSG比减少UVB曝光，两个主要的抗氧化酶，导致减少氧化DNA损伤和细胞凋亡和保护皮肤免受炎症引起的UVB曝光。本研究表明，槲皮苷作为抗氧化剂对UVB辐射诱导的皮肤氧化损伤的功能。
Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin.
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影响因子：
7.1
作者：
HOLLMAN, PCH;DEVRIES, JHM;KATAN, MB
通讯作者：
KATAN, MB
影响因子：
3.3
作者：
FUCHS, J;HUFLEJT, ME;PACKER, L
通讯作者：
PACKER, L
影响因子：
4.8
作者：
Ding, Wei;Liu, Wenlan;Liu, Ke Jian
通讯作者：
Liu, Ke Jian
影响因子：
2.9
作者：
HERTOG, MGL;HOLLMAN, PCH;KROMHOUT, D
通讯作者：
KROMHOUT, D
影响因子：
4.2
作者：
Belen Granado-Serrano, Ana;Angeles Martin, Maria;Ramos, Sonia
通讯作者：
Ramos, Sonia