Regulation of Gut Microbiota on Immune Reconstitution in Patients With Acquired Immunodeficiency Syndrome.
Regulation of Gut Microbiota on Immune Reconstitution in Patients With Acquired Immunodeficiency Syndrome.
复制标题
肠道微生物群对获得性免疫缺陷综合征患者免疫重建的调节。
DOI：
10.3389/fmicb.2020.594820
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发表时间：
2020
影响因子：
5.2
通讯作者：
Wang KH
中科院分区：
文献类型：
--
作者：
Geng ST;Zhang ZY;Wang YX;Lu D;Yu J;Zhang JB;Kuang YQ;Wang KH
人类免疫缺陷病毒1型（HIV-1）感染肠道中CD4+ T细胞在获得性免疫缺陷综合征（AIDS）发病机制中起着潜在的作用。宿主免疫功能与肠道菌群密切相关。肠道菌群的变化会引起不同的免疫反应。先前的研究表明，HIV-1感染引起肠道微生物群的变化，从而引起免疫缺陷。HIV-1感染导致肠道微生物群的组成和功能异常，这可能破坏肠上皮屏障和微生物易位，导致长期免疫激活，包括炎症和代谢紊乱。同时，肠道菌群异常也会阻碍抗病毒治疗的效果，影响患者的免疫重建。然而，关于肠道菌群对HIV/AIDS患者免疫重建影响的研究仍然有限。本文就HIV感染引起的肠道菌群变化、肠道菌群对免疫功能和免疫重建的影响及调控进行综述，同时探讨益生菌/益生元和粪便菌群移植（FMT）对免疫重建的潜在影响。
Human immunodeficiency virus type 1 (HIV-1) infection of CD4+ T cells in the gut plays an insidious role in acquired immunodeficiency syndrome (AIDS) pathogenesis. Host immune function is closely related to gut microbiota. Changes in the gut microbiota cause a different immune response. Previous studies revealed that HIV-1 infection caused changes in gut microbiota, which induced immune deficiency. HIV-1 infection results in an abnormal composition and function of the gut microbiota, which may disrupt the intestinal epithelial barrier and microbial translocation, leading to long-term immune activation, including inflammation and metabolic disorders. At the same time, an abnormal gut microbiota also hinders the effect of antiviral therapy and affects the immune reconstruction of patients. However, studies on the impact of the gut microbiota on immune reconstitution in patients with HIV/AIDS are still limited. In this review, we focus on changes in the gut microbiota caused by HIV infection, as well as the impact and regulation of the gut microbiota on immune function and immune reconstitution, while we also discuss the potential impact of probiotics/prebiotics and fecal microbiota transplantation (FMT) on immune reconstitution.
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影响因子：
3.7
作者：
Daka, Dawit Wolde;Ergiba, Meskerem Seboka
通讯作者：
Ergiba, Meskerem Seboka
影响因子：
3.8
作者：
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通讯作者：
Ferrer, Manuel
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
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Honda K
艾滋病毒感染中产生丁酸酯的细菌的丰度与微生物易位和免疫激活有关。
DOI：
10.1097/qad.0000000000001366
发表时间：
2017-02-20
期刊：
AIDS (London, England)
影响因子：
--
作者：
Dillon SM;Kibbie J;Lee EJ;Guo K;Santiago ML;Austin GL;Gianella S;Landay AL;Donovan AM;Frank DN;McCARTER MD;Wilson CC
通讯作者：
Wilson CC
影响因子：
64.5
作者：
An D;Oh SF;Olszak T;Neves JF;Avci FY;Erturk-Hasdemir D;Lu X;Zeissig S;Blumberg RS;Kasper DL
通讯作者：
Kasper DL