Landscape of transcription in human cells.
Landscape of transcription in human cells.
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DOI：
10.1038/nature11233
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发表时间：
2012-09-06
期刊：
影响因子：
64.8
通讯作者：
Gingeras, Thomas R.
中科院分区：
文献类型：
--
作者：
Djebali, Sarah;Davis, Carrie A.;Merkel, Angelika;Dobin, Alex;Lassmann, Timo;Mortazavi, Ali;Tanzer, Andrea;Lagarde, Julien;Lin, Wei;Schlesinger, Felix;Xue, Chenghai;Marinov, Georgi K.;Khatun, Jainab;Williams, Brian A.;Zaleski, Chris;Rozowsky, Joel;Roeder, Maik;Kokocinski, Felix;Abdelhamid, Rehab F.;Alioto, Tyler;Antoshechkin, Igor;Baer, Michael T.;Bar, Nadav S.;Batut, Philippe;Bell, Kimberly;Bell, Ian;Chakrabortty, Sudipto;Chen, Xian;Chrast, Jacqueline;Curado, Joao;Derrien, Thomas;Drenkow, Jorg;Dumais, Erica;Dumais, Jacqueline;Duttagupta, Radha;Falconnet, Emilie;Fastuca, Meagan;Fejes-Toth, Kata;Ferreira, Pedro;Foissac, Sylvain;Fullwood, Melissa J.;Gao, Hui;Gonzalez, David;Gordon, Assaf;Gunawardena, Harsha;Howald, Cedric;Jha, Sonali;Johnson, Rory;Kapranov, Philipp;King, Brandon;Kingswood, Colin;Luo, Oscar J.;Park, Eddie;Persaud, Kimberly;Preall, Jonathan B.;Ribeca, Paolo;Risk, Brian;Robyr, Daniel;Sammeth, Michael;Schaffer, Lorian;See, Lei-Hoon;Shahab, Atif;Skancke, Jorgen;Suzuki, Ana Maria;Takahashi, Hazuki;Tilgner, Hagen;Trout, Diane;Walters, Nathalie;Wang, Huaien;Wrobel, John;Yu, Yanbao;Ruan, Xiaoan;Hayashizaki, Yoshihide;Harrow, Jennifer;Gerstein, Mark;Hubbard, Tim;Reymond, Alexandre;Antonarakis, Stylianos E.;Hannon, Gregory;Giddings, Morgan C.;Ruan, Yijun;Wold, Barbara;Carninci, Piero;Guigo, Roderic;Gingeras, Thomas R.
真核细胞产生许多类型的初级和加工RNA，这些RNA存在于特定的亚细胞区室或整个细胞中。这些RNA的完整目录尚未提供，其特征性的亚细胞定位也知之甚少。由于RNA代表基因组编码的遗传信息的直接输出，并且细胞的调节能力的很大一部分集中在其合成、加工、运输、修饰和翻译上，因此产生这样的目录对于理解基因组功能至关重要。在这里，我们报告的证据表明，四分之三的人类基因组是能够被转录，以及观察的范围和水平的表达，定位，加工命运，调控区域和修饰的几乎所有目前注释和数以千计的以前未注释的RNA。这些观察结果加在一起，促使人们重新定义基因的概念。
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific sub-cellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic sub-cellular localizations are also poorly understood. Since RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell’s regulatory capabilities are focused on its synthesis, processing, transport, modifications and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations taken together prompt to a redefinition of the concept of a gene.
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影响因子：
56.9
作者：
Cheng, J;Kapranov, P;Gingeras, TR
通讯作者：
Gingeras, TR
影响因子：
56.9
作者：
Kapranov, Philipp;Cheng, Jill;Gingeras, Thomas R.
通讯作者：
Gingeras, Thomas R.
影响因子：
16.8
作者：
Ameur, Adam;Zaghlool, Ammar;Feuk, Lars
通讯作者：
Feuk, Lars
DOI：
10.1126/science.1207018
发表时间：
2011-07-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li M;Wang IX;Li Y;Bruzel A;Richards AL;Toung JM;Cheung VG
通讯作者：
Cheung VG
影响因子：
4.4
作者：
Kawaji H;Nakamura M;Takahashi Y;Sandelin A;Katayama S;Fukuda S;Daub CO;Kai C;Kawai J;Yasuda J;Carninci P;Hayashizaki Y
通讯作者：
Hayashizaki Y