Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population.
Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population.
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DOI：
10.1186/s12933-014-0126-7
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发表时间：
2014-08-21
影响因子：
9.3
通讯作者：
Miura T
中科院分区：
文献类型：
--
作者：
Fuseya T;Furuhashi M;Yuda S;Muranaka A;Kawamukai M;Mita T;Ishimura S;Watanabe Y;Hoshina K;Tanaka M;Ohno K;Akasaka H;Ohnishi H;Yoshida H;Saitoh S;Shimamoto K;Miura T
脂肪酸结合蛋白 4 (FABP4) 在脂肪细胞和巨噬细胞中表达。最近的研究表明脂肪细胞分泌 FABP4，血清 FABP4 水平升高与肥胖、胰岛素抵抗、高血压和动脉粥样硬化有关。然而，人们对 FABP4 在心脏功能中的作用知之甚少。从Tanno-Sobetsu研究的数据库中，检索了2011年或2012年未接受任何药物治疗并接受超声心动图检查的190名受试者（男性/女性：82/108）的数据，分析血清FABP4浓度、代谢标志物和超声心动图参数之间的关系。血清FABP4水平与年龄、体重指数（BMI）、血压（BP）、LDL胆固醇、HOMA-R和平均左心室（LV）壁厚度呈正相关（LVWT，男性：r = 0.315，女性：r = 0.401，p < 0.01），与HDL胆固醇、估计肾小球滤过率呈负相关 （eGFR）和舒张早期峰值心肌速度（e'；男性：r = −0.434，女性：r = −0.353，p < 0.01），左室舒张功能指数。然而，FABP4水平与左心室舒张末期尺寸、左心室射血分数或左心室质量指数之间没有发现显着相关性。 e’与年龄、BMI、BP、eGFR、脑钠肽（BNP）、FABP4、代谢标志物和 LVWT 显着相关。除年龄、性别和血压外，通过 HOMA-R、BMI、eGFR、BNP 或 LVWT 调整的多变量回归分析显示，血清 FABP4 浓度与 e' 独立相关。循环 FABP4 升高可能导致一般人群出现左心室舒张功能障碍。
Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function. From the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography. Serum FABP4 level was positively correlated with age, body mass index (BMI), blood pressure (BP), LDL cholesterol, HOMA-R and mean left ventricular (LV) wall thickness (LVWT, males: r = 0.315, females: r = 0.401, p < 0.01) and was negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and peak myocardial velocity during early diastole (e’; males: r = −0.434, females: r = −0.353, p < 0.01), an index of LV diastolic function. However, no significant correlation was found between FABP4 level and LV end-diastolic dimension, LV ejection fraction or LV mass index. There were significant correlations of e’ with age, BMI, BP, eGFR, brain natriuretic peptide (BNP), FABP4, metabolic markers and LVWT. Multivariate regression analysis adjusted by HOMA-R, BMI, eGFR, BNP or LVWT in addition to age, gender and BP revealed that serum FABP4 concentration was independently correlated with e’. Elevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population.
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血清脂肪酸结合蛋白 4 是终末期肾病心血管事件的预测因子。
影响因子：
3.7
作者：
Furuhashi M;Ishimura S;Ota H;Hayashi M;Nishitani T;Tanaka M;Yoshida H;Shimamoto K;Hotamisligil GS;Miura T
通讯作者：
Miura T
影响因子：
2
作者：
Furuhashi M;Ishimura S;Ota H;Miura T
通讯作者：
Miura T
影响因子：
9.3
作者：
Ichikawa R;Daimon M;Miyazaki T;Kawata T;Miyazaki S;Maruyama M;Chiang SJ;Suzuki H;Ito C;Sato F;Watada H;Daida H
通讯作者：
Daida H
影响因子：
9.3
作者：
Huang, Chi-Lun;Wu, Yen-Wen;Yang, Wei-Shiung
通讯作者：
Yang, Wei-Shiung
影响因子：
3.2
作者：
Ota, Hideki;Furuhashi, Masato;Ishimura, Shutaro;Koyama, Masayuki;Okazaki, Yusuke;Mita, Tomohiro;Fuseya, Takahiro;Yamashita, Tomohisa;Tanaka, Marenao;Yoshida, Hideaki;Shimamoto, Kazuaki;Miura, Tetsuji
通讯作者：
Miura, Tetsuji