Multimodality imaging of the effects of a novel dentifrice on oral biofilm.
Multimodality imaging of the effects of a novel dentifrice on oral biofilm.
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DOI：
10.1002/lsm.22265
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发表时间：
2014-09
影响因子：
2.4
通讯作者：
Wilder-Smith, Petra
中科院分区：
文献类型：
--
作者：
Ajdaharian, Janet;Dadkhah, Mohammad;Sabokpey, Sara;Biren-Fetz, John;Chung, Na Eun;Wink, Cherie;Wilder-Smith, Petra
关键词：
口腔生物膜在牙齿表面的形成和发展可导致晚期口腔疾病，如牙龈炎。这项随机、对照、双盲研究的目的是利用多模态成像技术评估一种新型牙科凝胶对口腔菌斑生物膜的影响。随机选取25名中度牙龈炎症（Löe, Silness gingval Index≥2）且牙袋深度<4的受试者，每天刷2次，连续21天使用测试组或对照牙凝胶。使用体内光学相干断层扫描（OCT）和非线性光学显微镜（NLOM）进行为期3周的体内多模态原位成像。使用标准临床指标，在第0、7、14和21天绘制牙菌斑水平、牙龈炎症和牙龈出血的图表。3周后，OCT和NLOM图像显示，试验组斑块层宏观破裂，残余沉积物较小，碎片化，膜没有明显变化。对照组的生物膜也减少了，但在厚度、连续性和表面积方面减少的程度较轻。与影像学结果比较，两组临床指标均显著改善（P <0.05），试验组临床指标均显著降低（P <0.05）。两种牙凝胶均能减少口腔生物膜，临床和影像学指标显示，试验凝胶效果更佳（P <0.05）。
Oral biofilm formation and progression on the surface of the tooth can lead to advanced oral disease such as gingivitis. The purpose of this randomized, controlled, double-blinded study was to evaluate the effects of a novel dental gel on oral plaque biofilm using multimodal imaging techniques. Twenty-five subjects with moderate gingival inflammation (Löe and Silness Gingival Index ≥ 2) and pocket depths <4 were randomly assigned to brush twice daily for 21 days with the test or the control dental gel. In vivo multimodality in situ imaging was performed over a 3-week period using in vivo Optical Coherence Tomography (OCT) and Non-Linear Optical microscopy (NLOM). Plaque levels, gingival inflammation and gingival bleeding were also charted on days 0, 7, 14, and 21 using standard clinical indices. After 3 weeks, OCT and NLOM images showed a macroscopic break-up of the plaque layer and smaller, fragmented residual deposits in the test group with no apparent changes in the pellicle. Biofilm was also reduced in the control group, but to a lesser degree with regard to thickness, continuity and surface area. Paralleling these imaging results, clinical indices were significantly improved in both groups (P <0.05) and significantly lower in the test group (P <0.05). Both dental gels reduced oral biofilm with the test gel showing greater efficacy (P <0.05) as determined by clinical and imaging parameters.
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影响因子：
4.2
作者：
Jeon JG;Rosalen PL;Falsetta ML;Koo H
通讯作者：
Koo H
影响因子：
1.9
作者：
Fraud, S.;Maillard, J. -Y.;Hanlon, G. W.
通讯作者：
Hanlon, G. W.
影响因子：
6.7
作者：
AXELSSON, P;LINDHE, J
通讯作者：
LINDHE, J
使用交叉极化光学相干断层扫描中的体内次要龋齿和离体牙科生物膜进行成像。
影响因子：
5
作者：
Lenton, Pat;Rudney, Joel;Chen, Ruoqiong;Fok, Alex;Aparicio, Conrado;Jones, Robert S.
通讯作者：
Jones, Robert S.
影响因子：
6.7
作者：
Nogueira, GR;Toledo, S;Cury, JA
通讯作者：
Cury, JA