Diversity in gut bacterial community of school-age children in Asia.
Diversity in gut bacterial community of school-age children in Asia.
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DOI：
10.1038/srep08397
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发表时间：
2015-02-23
影响因子：
4.6
通讯作者：
Lee YK
中科院分区：
文献类型：
--
作者：
Nakayama J;Watanabe K;Jiang J;Matsuda K;Chao SH;Haryono P;La-Ongkham O;Sarwoko MA;Sujaya IN;Zhao L;Chen KT;Chen YP;Chiu HH;Hidaka T;Huang NX;Kiyohara C;Kurakawa T;Sakamoto N;Sonomoto K;Tashiro K;Tsuji H;Chen MJ;Leelavatcharamas V;Liao CC;Nitisinprasert S;Rahayu ES;Ren FZ;Tsai YC;Lee YK
亚洲在不同民族居住的地区之间和地区内有很大的不同，这些民族保持着自己的文化和饮食习惯。为了解决他们肠道微生物区系的多样性，我们从生活在亚洲温带和热带地区的五个国家的303名学龄儿童的粪便样本中表征了细菌群落。303名受试者的微生物区系被归类为两个肠型集群，每个集群分别由普氏杆菌(P型)或双歧杆菌/类杆菌(BB型)驱动。中国、日本和台湾地区以BB型居多，印尼和泰国坤干地区以P型为主。P型微生物群的特征是具有更保守的细菌群落，共享更多的特定类型的系统类型。预测元基因组学表明，P型受试者的碳水化合物消化和胆汁酸生物合成活性分别较高和较低，这反映了他们对富含抗性淀粉的饮食的高摄入量。随机森林分析将它们的粪便物种群落归类为反映居住地的位置，表明生态地理因素塑造了肠道微生物区系。特别是，生活在日本的儿童拥有多样性较差的微生物群，双歧杆菌丰度高，潜在致病细菌数量较少，这可能反映了他们的生活环境和独特的饮食。
Asia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures and dietary habits. To address the diversity in their gut microbiota, we characterized the bacterial community in fecal samples obtained from 303 school-age children living in urban or rural regions in five countries spanning temperate and tropical areas of Asia. The microbiota profiled for the 303 subjects were classified into two enterotype-like clusters, each driven by Prevotella (P-type) or Bifidobacterium/Bacteroides (BB-type), respectively. Majority in China, Japan and Taiwan harbored BB-type, whereas those from Indonesia and Khon Kaen in Thailand mainly harbored P-type. The P-type microbiota was characterized by a more conserved bacterial community sharing a greater number of type-specific phylotypes. Predictive metagenomics suggests higher and lower activity of carbohydrate digestion and bile acid biosynthesis, respectively, in P-type subjects, reflecting their high intake of diets rich in resistant starch. Random-forest analysis classified their fecal species community as mirroring location of resident country, suggesting eco-geographical factors shaping gut microbiota. In particular, children living in Japan harbored a less diversified microbiota with high abundance of Bifidobacterium and less number of potentially pathogenic bacteria, which may reflect their living environment and unique diet.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
12.3
作者：
Kinross JM;Darzi AW;Nicholson JK
通讯作者：
Nicholson JK
影响因子：
5.7
作者：
Brüssow H
通讯作者：
Brüssow H
影响因子：
24.5
作者：
Joossens, Marie;Huys, Geert;Vermeire, Severine
通讯作者：
Vermeire, Severine