Comparative Review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza A Respiratory Viruses.

Comparative Review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza A Respiratory Viruses.
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DOI:
10.3389/fimmu.2020.552909
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发表时间:
2020
影响因子:
7.3
通讯作者:
Wang X
Wang X
中科院分区:
医学2区
文献类型:
--
作者:
Abdelrahman Z;Li M;Wang X

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2019年新型冠状病毒(SARS-CoV-2)大流行引发了全球卫生紧急情况。这种病毒的爆发引发了许多问题:什么是SARS-CoV-2?SARS-CoV-2的传染性如何?感染SARS-CoV-2的患者受到的影响有多严重?病毒感染的危险因素有哪些?这种新型冠状病毒与其他冠状病毒有何不同?为了回答这些问题,我们对主要攻击呼吸系统并可能导致死亡的四种致病病毒进行了比较研究,即SARS-CoV-2、严重急性呼吸综合征(SARS-CoV)、中东呼吸综合征(MERS-CoV)和甲型流感病毒(H1N1和H3 N2株)。这项比较研究对这些病毒的起源、基因组特征、传播和致病性进行了重要评价。由于由SARS-CoV-2引起的2019冠状病毒病(COVID-19)大流行正在进行中,这项评估可能会告知公共卫生管理人员和医学专家,以帮助遏制大流行的进展。
The 2019 novel coronavirus (SARS-CoV-2) pandemic has caused a global health emergency. The outbreak of this virus has raised a number of questions: What is SARS-CoV-2? How transmissible is SARS-CoV-2? How severely affected are patients infected with SARS-CoV-2? What are the risk factors for viral infection? What are the differences between this novel coronavirus and other coronaviruses? To answer these questions, we performed a comparative study of four pathogenic viruses that primarily attack the respiratory system and may cause death, namely, SARS-CoV-2, severe acute respiratory syndrome (SARS-CoV), Middle East respiratory syndrome (MERS-CoV), and influenza A viruses (H1N1 and H3N2 strains). This comparative study provides a critical evaluation of the origin, genomic features, transmission, and pathogenicity of these viruses. Because the coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 is ongoing, this evaluation may inform public health administrators and medical experts to aid in curbing the pandemic's progression.
DOI: 10.1128/mbio.00884-14
发表时间: 2014-02-25
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影响因子: --
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