The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.
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DOI:
10.1371/journal.pone.0268700
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发表时间:
2022
期刊:
影响因子:
3.7
通讯作者:
--
中科院分区:
综合性期刊3区
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--
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本研究在规范衰老研究(NAS)队列中调查了太阳和地磁活动与全身炎症和内皮细胞激活的循环生物标志物之间的关系。采用从第0天到第28天移动日平均的混合效应模型,研究了太阳活动(太阳黑子数(SSN)、行星际磁场(IMF))、地磁活动(行星K指数(Kp指数))与各种炎症和内皮标志物之间的关系。生物标志物包括细胞内粘附分子-1 (sICAM-1)、血管细胞粘附分子-1 (sVCAM-1)、c反应蛋白(CRP)和纤维蛋白原。在调整了人口统计和气象变量后,我们观察到sICAM-1和sVCAM-1浓度与太阳和地磁活动参数(IMF、SSN和Kp)之间存在显著的正相关。此外,纤维蛋白原与Kp指数呈负相关,CRP与SSN呈正相关。这些结果表明,太阳和地磁活动可能上调内皮细胞的激活和炎症。
This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic activity (planetary K index (Kp index), and various inflammatory and endothelial markers. Biomarkers included intracellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), C-reactive protein (CRP), and fibrinogen. After adjusting for demographic and meteorological variables, we observed significant positive associations between sICAM-1 and sVCAM-1 concentrations and solar and geomagnetic activity parameters: IMF, SSN, and Kp. Additionally, a negative association was observed between fibrinogen and Kp index and a positive association was observed for CRP and SSN. These results demonstrate that solar and geomagnetic activity might be upregulating endothelial activation and inflammation.
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