Encoding innately recognized odors via a generalized population code.
Encoding innately recognized odors via a generalized population code.
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通过一个广义的种群编码来编码先天识别的气味。
DOI：
10.1016/j.cub.2021.01.094
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发表时间：
2021-05-10
期刊：
影响因子：
--
通讯作者：
Yu CR
中科院分区：
文献类型：
--
作者：
Qiu Q;Wu Y;Ma L;Yu CR
具有内在价值的气味常常引发本能的厌恶或吸引反应。先天效价是如何编码的尚不清楚。一种直观的模型表明，信息是通过嗅觉通路中硬连线回路的特定通道传递的，不受其他气味的影响，从而引发先天反应。在此，我们发现，在小鼠中，将先天厌恶或吸引的气味与一种中性气味混合，令人惊讶的是，将两种具有相同效价的气味混合，会消除先天的行为反应。嗅球的记录表明，气味在外周激活水平上没有被掩盖，而且肾小球独立地对混合物中的成分进行编码。相比之下，僧帽细胞和簇状细胞（M/T细胞）之间的串扰改变了它们的活动模式，使得由混合物引发的活动模式不再能作为独立的成分进行线性解码。行为和M/T细胞反应的变化与与气味偏好相关的大脑区域激活减少有关。因此，嗅觉通路中最早的处理阶段气味通道之间的串扰导致气味特性的重新编码，从而消除与气味相关的效价。这些结果与绝缘标记线路不符，并支持一种先天和后天习得的效价关联的气味识别通用机制模型。
邱等人发现气味混合物消除了对成分气味的先天反应。嗅球的记录表明僧帽/簇状细胞之间存在显著的串扰，以一种依赖于环境的方式对气味进行编码。这些结果与绝缘标记线路模型不符，并表明了一种先天气味编码的通用编码。
Odors carrying intrinsic values often trigger instinctive aversive or attractive responses. It is not known how innate valence is encoded. An intuitive model suggests that the information is conveyed through specific channels in hardwired circuits along the olfactory pathway, insulated from influences of other odors, to trigger innate responses. Here, we show that in mice, mixing innately aversive or attractive odors with a neutral odor and, surprisingly, mixing two odors with the same valence, abolish the innate behavioral responses. Recordings from the olfactory bulb indicate that odors are not masked at the level of peripheral activation and glomeruli independently encode components in the mixture. In contrast, crosstalk among the mitral and tufted (M/T) cells changes their patterns of activity such that those elicited by the mixtures can no longer be linearly decoded as separate components. The changes in behavioral and M/T cell responses are associated with reduced activation of brain areas linked to odor preferences. Thus, crosstalk among odor channels at the earliest processing stage in the olfactory pathway leads to re-coding of odor identity to abolish valence associated with the odors. These results are inconsistent with insulated labeled lines and support a model of a common mechanism of odor recognition for both innate and learned valence associations. Qiu et al. find that odor mixtures abolish innate responses to the component odors. Recordings from the olfactory bulb demonstrate significant crosstalk among mitral/tufted cells to encode odors in a context-dependent manner. These results are inconsistent with insulated labeled-line model and suggest a generalized code for innate odor encoding.
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影响因子：
8.2
作者：
Canteras, NS;Ribeiro-Barbosa, ÉR;Comoli, E
通讯作者：
Comoli, E
影响因子：
15.9
作者：
Carleton A;Accolla R;Simon SA
通讯作者：
Simon SA
通过在嗅球肾小球中选择性抑制对二尖瓣/簇状细胞输出的控制。
影响因子：
16.2
作者：
Economo MN;Hansen KR;Wachowiak M
通讯作者：
Wachowiak M
DOI：
10.1073/pnas.88.15.6462
发表时间：
1991-08-01
影响因子：
11.1
作者：
HOPFIELD, JJ
通讯作者：
HOPFIELD, JJ
影响因子：
64.8
作者：
Haga, Sachiko;Hattori, Tatsuya;Touhara, Kazushige
通讯作者：
Touhara, Kazushige