Association between infection early in life and mental disorders among youth in the community: a cross-sectional study.

Association between infection early in life and mental disorders among youth in the community: a cross-sectional study.
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生活早期感染与社区青年的精神障碍之间的关联:一项横断面研究。

DOI:
10.1186/1471-2458-11-878
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发表时间:
2011-11-21
期刊:
影响因子:
4.5
通讯作者:
Goodwin RD
Goodwin RD
中科院分区:
医学2区
文献类型:
--
作者:
Goodwin RD

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The objective of this study was to examine the association between infection early in life and mental disorders among youth in the community. Data were drawn from the MECA (Methods in Epidemiology of Child and Adolescent psychopathology), a community-based study of 1,285 youth in the United States conducted in 1992. Multiple logistic regression analyses were used to investigate the association between parent/caregiver-reported infection early in life and DSM/DISC diagnoses of mental disorders at ages 9-17. Infection early in life was associated with a significantly increased odds of major depression (OR = 3.9), social phobia (OR = 5.8), overanxious disorder (OR = 6.1), panic disorder (OR = 12.1), and oppositional defiant disorder (OR = 3.7). These findings are consistent with and extend previous results by providing new evidence suggesting a link between infection early in life and increased risk of depression and anxiety disorders among youth. These results should be considered preliminary. Replication of these findings with longitudinal epidemiologic data is needed. Possible mechanisms are discussed.
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