Dietary lignan intakes in relation to survival among women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study.
Dietary lignan intakes in relation to survival among women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study.
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DOI：
10.1007/s10549-009-0681-x
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发表时间：
2010-07
影响因子：
3.8
通讯作者：
Freudenheim JL
中科院分区：
文献类型：
--
作者：
McCann SE;Thompson LU;Nie J;Dorn J;Trevisan M;Shields PG;Ambrosone CB;Edge SB;Li HF;Kasprzak C;Freudenheim JL
膳食木酚素摄入量与降低乳腺癌风险有关;然而，以前没有研究调查木酚素摄入量是否与乳腺癌生存率有关。我们研究了1122例原发性、偶发性、组织学证实的乳腺癌患者的饮食木脂素摄入量与生存率的关系，这些患者在1996年至2001年期间被确定为乳腺癌，并在2006年12月31日之前确定了生命状态。诊断前12-24个月的饮食情况通过广泛的食物频率问卷进行评估，潜在的混杂因素通过广泛的流行病学访谈和抽象的临床数据进行评估。木脂素的摄入量使用已发表的食物组成数据计算。采用校正年龄、教育程度、种族、总能量摄入、肿瘤分期和体重指数的考克斯比例风险，估计全因膳食木酚素摄入和乳腺癌死亡率的风险比（HR）和95%置信区间（CI）。在1122名有完整饮食数据的女性中，有160人在随访结束时死亡。仅在绝经后妇女中，木脂素摄入量最高与最低四分位数的妇女全因死亡风险显著降低（HR 0.49，95% CI 0.26-0.91），乳腺癌死亡风险显著降低（HR 0.29，95% CI 0.11-0.76）。较高的干豆摄入量（HR 0.61，95% CI 0.36-1.03），而不是水果，蔬菜或谷物，也与总死亡率弱相关。总之，我们的研究结果表明，较高的木脂素摄入量可能与改善绝经后乳腺癌妇女的生存率有关。
Dietary lignan intakes have been associated with reduced breast cancer risks; however, no previous studies have investigated whether lignan intake might be associated with breast cancer survival. We examined the association of dietary lignan intakes with survival in 1122 women with primary, incident, histologically confirmed breast cancer identified between 1996 and 2001, and with vital status determined through December 31, 2006. Diet in the 12–24 months before diagnosis was assessed with an extensive food frequency questionnaire, and potential confounders assessed from an extensive epidemiologic interview and abstracted clinical data. Lignan intake was calculated using published food composition data. Hazard ratios (HR), and 95% confidence intervals (CIs) for dietary lignan intakes with all cause, and breast cancer mortality were estimated using Cox proportional hazards adjusting for age, education, race, total energy intake, tumor stage, and body mass index. Of the 1122 women with complete dietary data, 160 had died by the end of follow-up. Among postmenopausal women only, those in the highest versus lowest quartile of lignan intakes had a statistically significant reduction in the risk of all cause mortality (HR 0.49, 95% CI 0.26–0.91) and a significantly reduced risk of breast cancer mortality (HR 0.29, 95% CI 0.11–0.76). Higher intakes of dried beans (HR 0.61, 95% CI 0.36–1.03), but not fruits, vegetables, or grains, were also weakly associated with overall mortality. In summary, our results suggest that higher lignan intakes may be associated with improved survival among postmenopausal women with breast cancer.
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DOI：
10.1016/j.jamcollsurg.2008.12.001
发表时间：
2009-03
影响因子：
5.2
作者：
Gnerlich, Jennifer L.;Deshpande, Anjali D.;Jeffe, Donna B.;Sweet, Allison;White, Nick;Margenthaler, Julie A.
通讯作者：
Margenthaler, Julie A.
DOI：
10.1080/07315724.2003.10719335
发表时间：
2003-12-01
影响因子：
3.5
作者：
Frische, EJ;Hutchins, AM;Slavin, JL
通讯作者：
Slavin, JL
影响因子：
6.4
作者：
Dal Maso, Luigino;Zucchetto, Antonella;Franceschi, Silvia
通讯作者：
Franceschi, Silvia
DOI：
10.1016/j.jsbmb.2005.02.002
发表时间：
2005-04-01
影响因子：
4.1
作者：
Brooks, JD;Thompson, LU
通讯作者：
Thompson, LU
影响因子：
2.3
作者：
Han, DW;Rogerson, PA;Freudenheim, JL
通讯作者：
Freudenheim, JL