Relationship between microelectrode array impedance and chronic recording quality of single units and local field potentials.
Relationship between microelectrode array impedance and chronic recording quality of single units and local field potentials.
复制标题
微电极阵列阻抗与单个单元的长期记录质量和局部场电位之间的关系。
DOI：
10.1109/embc.2014.6944265
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Taylor,DawnM
中科院分区：
文献类型：
--
作者：
Jiang,JingLe;Willett,FrancisR;Taylor,DawnM
Practical application of intracortical microelectrode technology is currently hindered by the inability to reliably record neuronal signals chronically. The precise mechanism of device failure is still under debate, but most likely includes some combination of tissue reaction, mechanical failure, and chronic material degradation. Impedance is a measure of the ease with which current flows through a working electrode under a driving voltage. Impedance has been hypothesized to provide information about an electrode's surrounding tissue reaction as well as chronic insulation degradation. In this study, we investigated the relationship between an electrode's impedance and its chronic recording performance as measured by the number of isolatable single units and the quality of local field potential recordings. Two 64-channel electrode arrays implanted in separate monkeys were assessed. We found no simple relationship between impedance and recording quality that held for both animals across all time periods. This suggests that future investigations on the topic should adopt a more fine-grained within-day and within-animal analysis. We also found new evidence from local field potential spatial correlation supporting the theory that insulation degradation is an important contributor to electrode failure.
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DOI：
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DOI：
10.1016/s0021-9258(18)89809-x
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1984
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The Journal of biological chemistry
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