Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology.

Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology.
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DOI:
10.1016/j.neuron.2021.06.016
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发表时间:
2021-09-15
期刊:
影响因子:
16.2
通讯作者:
Satterthwaite TD
Satterthwaite TD
中科院分区:
医学1区
文献类型:
--
作者:
Sydnor VJ;Larsen B;Bassett DS;Alexander-Bloch A;Fair DA;Liston C;Mackey AP;Milham MP;Pines A;Roalf DR;Seidlitz J;Xu T;Raznahan A;Satterthwaite TD

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The human brain undergoes a prolonged period of cortical development that spans multiple decades. During childhood and adolescence, cortical development progresses from lower order, primary and unimodal cortices with sensory and motor functions to higher order, transmodal association cortices subserving executive, socioemotional, and mentalizing functions. The spatiotemporal patterning of cortical maturation thus proceeds in a hierarchical manner, conforming to an evolutionarily rooted, sensorimotor-to-association axis of cortical organization. This developmental program has been characterized by data derived from multimodal human neuroimaging and is linked to the hierarchical unfolding of plasticity-related neurobiological events. Critically, this developmental program serves to enhance feature variation between lower order and higher order regions, thus endowing the brain’s association cortices with unique functional properties. However, accumulating evidence suggests that protracted plasticity within late-maturing association cortices, which represents a defining feature of the human developmental program, also confers risk for diverse developmental psychopathologies.
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