Theta-burst TMS of lateral occipital cortex reduces BOLD responses across category-selective areas in ventral temporal cortex.
Theta-burst TMS of lateral occipital cortex reduces BOLD responses across category-selective areas in ventral temporal cortex.
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枕叶外侧皮质的Theta-Burst TMS减少了在颞叶腹侧皮质类别选择区域的大胆反应。
DOI：
10.1016/j.neuroimage.2021.117790
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发表时间：
2021-04-15
期刊：
影响因子：
5.7
通讯作者：
Baker CI
中科院分区：
文献类型：
--
作者：
Groen IIA;Silson EH;Pitcher D;Baker CI
人眼视皮质在外侧、内侧和腹侧皮质有三个场景选择区域，分别称为枕区(OPA)、内侧区(MPA)和海马旁区(PPA)。使用功能磁共振成像(FMRI)，与孤立的物体或人脸相比，在观看视觉场景时，所有三个区域的反应都更强烈。为了确定这些区域在功能和因果关系上是如何联系的，我们对OPA进行了经颅磁刺激，并使用theta-Burst范式(TBS)测量了刺激前后的fMRI反应。为了测试刺激类别的选择性，我们展示了一系列视觉类别(场景、建筑物、物体、面部)。为了测试OPA对TBS的影响的特异性，我们采用了两种对照条件：假刺激，没有TBS刺激，以及TBS对近侧面部选择性皮质区域(枕面部区域，OFA)的主动TBS对照。我们预测，TBS到OPA(而不是OFA)会导致对其他场景选择皮层区域的场景和建筑(但不是其他类别)的反应减弱。通过ROI和全容量分析，我们观察到由于TBS的结果，PPA中对场景的响应减少。然而，这些效应既不是类别特异性的，对所有刺激类别的反应都会降低，也不限于场景选择区域，面部选择梭状脸区域(FFA)的反应也会减少。此外，TBS的作用与OFA相似，因此作用不是针对枕叶外侧皮质的刺激部位。虽然这些数据暗示了侧枕皮质和腹侧颞叶皮质之间的因果关系，但我们讨论了几个可能支持这一结果的因素，例如TBS和在线TMS之间的差异，刺激区域之间的解剖距离的作用以及TMS效应是如何操作的。此外，我们的发现强调了脑刺激实验中主动控制条件的重要性，以准确评估特定大脑区域之间的功能和因果连接。
Human visual cortex contains three scene-selective regions in the lateral, medial and ventral cortex, termed the occipital place area (OPA), medial place area (MPA) and parahippocampal place area (PPA). Using functional magnetic resonance imaging (fMRI), all three regions respond more strongly when viewing visual scenes compared with isolated objects or faces. To determine how these regions are functionally and causally connected, we applied transcranial magnetic stimulation to OPA and measured fMRI responses before and after stimulation, using a theta-burst paradigm (TBS). To test for stimulus category-selectivity, we presented a range of visual categories (scenes, buildings, objects, faces). To test for specificity of any effects to TBS of OPA we employed two control conditions: Sham, with no TBS stimulation, and an active TBS-control with TBS to a proximal face-selective cortical region (occipital face area, or OFA). We predicted that TBS to OPA (but not OFA) would lead to decreased responses to scenes and buildings (but not other categories) in other scene-selective cortical regions. Across both ROI and whole-volume analyses, we observed decreased responses to scenes in PPA as a result of TBS. However, these effects were neither category specific, with decreased responses to all stimulus categories, nor limited to scene-selective regions, with decreases also observed in face-selective fusiform face area (FFA). Furthermore, similar effects were observed with TBS to OFA, thus effects were not specific to the stimulation site in the lateral occipital cortex. Whilst these data are suggestive of a causal, but non-specific relationship between lateral occipital and ventral temporal cortex, we discuss several factors that could have underpinned this result, such as the differences between TBS and online TMS, the role of anatomical distance between stimulated regions and how TMS effects are operationalised. Furthermore, our findings highlight the importance of active control conditions in brain stimulation experiments to accurately assess functional and causal connectivity between specific brain regions.
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枕叶区域在导航过程中代表环境边界有因果关系。
DOI：
10.1016/j.cub.2016.02.066
发表时间：
2016-04-25
期刊：
Current biology : CB
影响因子：
--
作者：
Julian JB;Ryan J;Hamilton RH;Epstein RA
通讯作者：
Epstein RA
影响因子：
5.7
作者：
Baldassano, Christopher;Beck, Diane M.;Fei-Fei, Li
通讯作者：
Fei-Fei, Li
影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
影响因子：
3.2
作者：
Gauthier, I;Tarr, MJ;Anderson, AW
通讯作者：
Anderson, AW
DOI：
10.1073/pnas.92.18.8135
发表时间：
1995-08-29
影响因子：
11.1
作者：
MALACH, R;REPPAS, JB;TOOTELL, RBH
通讯作者：
TOOTELL, RBH