The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury.
The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury.
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DOI：
10.1016/j.neubiorev.2021.08.029
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发表时间：
2021-11
影响因子：
8.2
通讯作者：
Kawata K
中科院分区：
文献类型：
--
作者：
Huibregtse ME;Bazarian JJ;Shultz SR;Kawata K
李晓明，李晓明，李晓明，李晓明。血液生物标志物在创伤性脑损伤中的生物学意义和临床应用。中国生物医学工程学报，2016,31(3):387 - 387。血液生物标志物可以作为衡量创伤性脑损伤（TBI）严重程度的客观指标，识别有不良后果风险的患者，并预测恢复时间，然而，血液生物标志物在TBI中的临床应用仅限于少数，并且仅用于排除CT扫描的需要。神经创伤研究中经常检测的生物标志物是蛋白质组学标志物，它可以反映一系列病理过程，如细胞损伤、星形胶质增生或神经炎症。然而，蛋白质组血液生物标志物易降解，导致半衰期短。新出现的TBI生物标志物可能反映了TBI后发生的复杂遗传和神经代谢改变，这些改变不被蛋白质组学捕获，不易降解，由microRNA、细胞外囊泡和神经代谢物组成。因此，本综述旨在总结我们对脑损伤的生物标志物如何逃离脑实质空间并出现在血液中的理解，更新几种蛋白质组学生物标志物的最新研究成果，并表征microRNA、细胞外囊泡和神经代谢物的生物学意义和临床应用。
HUIBREGTSE, M.E, Bazarian, J.J., Shultz, S.R., and Kawata K. The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury. NEUROSCI BIOBEHAV REV XX (130) XXX-XXX, 2021.-Blood biomarkers can serve as objective measures to gauge traumatic brain injury (TBI) severity, identify patients at risk for adverse outcomes, and predict recovery duration, yet the clinical use of blood biomarkers for TBI is limited to a select few and only to rule out the need for CT scanning. The biomarkers often examined in neurotrauma research are proteomic markers, which can reflect a range of pathological processes such as cellular damage, astrogliosis, or neuroinflammation. However, proteomic blood biomarkers are vulnerable to degradation, resulting in short half-lives. Emerging biomarkers for TBI may reflect the complex genetic and neurometabolic alterations that occur following TBI that are not captured by proteomics, are less vulnerable to degradation, and are comprised of microRNA, extracellular vesicles, and neurometabolites. Therefore, this review aims to summarize our understanding of how biomarkers for brain injury escape the brain parenchymal space and appear in the bloodstream, update recent research findings in several proteomic biomarkers, and characterize biological significance and examine clinical utility of microRNA, extracellular vesicles, and neurometabolites.
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