ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection.
ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection.
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DOI：
10.1038/nn.3897
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发表时间：
2015-01
影响因子：
25
通讯作者：
Li, Bo
中科院分区：
文献类型：
--
作者：
Ahrens, Sandra;Jaramillo, Santiago;Yu, Kai;Ghosh, Sanchari;Hwang, Ga-Ram;Paik, Raehum;Lai, Cary;He, Miao;Huang, Z. Josh;Li, Bo
选择性处理行为相关的感觉输入对不相关的是一个基本的认知功能，其损害已牵连到主要的精神疾病。已知丘脑网状核（TRN）在通往皮层的途中门控感觉信息，但其潜在机制尚不清楚。在这里，我们表明在小鼠中，Erbb 4基因在生长抑素表达TRN神经元的缺陷显着改变依赖于感觉选择的行为。虽然从干扰物中识别目标的能力得到了提高，但在相互冲突的感官线索之间切换注意力的能力却受到了损害。这些行为变化是由增强的皮质驱动TRN，促进TRN介导的丘脑神经元的皮质反馈抑制。我们的研究结果揭示了ErbB 4在调节皮质-TRN-丘脑回路功能中的一个先前未知的作用。我们认为ErbB 4将TRN对皮层输入的敏感性设置在可以支持感官选择的水平，同时允许行为灵活性。
Selective processing of behaviorally relevant sensory inputs against irrelevant ones is a fundamental cognitive function, impairments of which have been implicated in major psychiatric disorders. It is known that the thalamic reticular nucleus (TRN) gates sensory information en route to the cortex, however the underlying mechanisms remain unclear. Here we show in mice that deficiency of Erbb4 gene in somatostatin-expressing TRN neurons markedly altered behaviors dependent on sensory selection. Whereas performance in identifying targets from distractors was improved, the ability to switch attention between conflicting sensory cues was impaired. These behavioral changes were mediated by enhanced cortical drive onto TRN that promotes the TRN-mediated cortical feedback inhibition of thalamic neurons. Our results uncover a previously unknown role of ErbB4 in regulating cortico-TRN-thalamic circuit function. We propose that ErbB4 sets the sensitivity of TRN to cortical inputs at levels that can support sensory selection while allowing behavioral flexibility.
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影响因子：
25
作者：
Li, Haohong;Penzo, Mario A.;Taniguchi, Hiroki;Kopec, Charles D.;Huang, Z. Josh;Li, Bo
通讯作者：
Li, Bo
影响因子：
2.5
作者：
Cooper, Margaret A.;Koleske, Anthony J.
通讯作者：
Koleske, Anthony J.
影响因子：
25
作者：
Jaramillo, Santiago;Zador, Anthony M.
通讯作者：
Zador, Anthony M.
DOI：
10.3109/00207459308987213
发表时间：
1993-11-01
期刊：
The International journal of neuroscience
影响因子：
--
作者：
Bucherelli, C;Tassoni, G;Bures, J
通讯作者：
Bures, J
DOI：
10.1073/pnas.1010669107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Chen, Yong-Jun;Zhang, Meng;Gao, Tian-Ming
通讯作者：
Gao, Tian-Ming