Dose-dependent effects of testosterone on spatial learning strategies and brain-derived neurotrophic factor in male rats.
Dose-dependent effects of testosterone on spatial learning strategies and brain-derived neurotrophic factor in male rats.
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DOI：
10.1016/j.psyneuen.2020.104850
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发表时间：
2020-11
影响因子：
3.7
通讯作者：
Spritzer MD
中科院分区：
文献类型：
--
作者：
Zhang KJ;Ramdev RA;Tuta NJ;Spritzer MD
研究表明，男性在某些空间任务上的表现优于女性。这可能是由于性类固醇对空间策略偏好的影响。过去对雄性大鼠的实验表明，低剂量的睾丸激素使它们偏向于反应策略，而高剂量的睾丸激素使它们偏向于位置策略。我们研究了不同剂量的睾酮对雄性大鼠有效利用这两种空间学习策略的能力的影响。此外，我们定量的浓度脑源性神经营养因子（前，成熟和总BDNF）在前额叶皮层，海马和纹状体。将所有大鼠双侧去势，并分配至丙酸睾酮（0.125、0.250或0.500 mg/大鼠）的三种每日注射剂量之一或药物溶媒的对照注射。使用十字迷宫方案，我们发现，较低的睾酮剂量（0.125 mg）显着提高大鼠的反应任务的性能，而较高的睾酮剂量（0.500 mg）显着提高大鼠的位置任务的性能。此外，我们发现低剂量的睾酮（0.125 mg）增加了纹状体中的总BDNF，而高剂量（0.500 mg）增加了海马中的总BDNF。总而言之，这些结果表明，高水平和低水平的睾酮分别增强了位置和响应空间任务的表现，这种效果与相关大脑区域内BDNF水平的变化有关。
Studies suggest that males outperform females on some spatial tasks. This may be due to the effects of sex steroids on spatial strategy preferences. Past experiments with male rats have demonstrated that low doses of testosterone bias them toward a response strategy, whereas high doses of testosterone bias them toward a place strategy. We investigated the effect of different testosterone doses on the ability of male rats to effectively employ these two spatial learning strategies. Furthermore, we quantified concentrations of brain-derived neurotrophic factor (pro-, mature-, and total BDNF) in the prefrontal cortex, hippocampus, and striatum. All rats were bilaterally castrated and assigned to one of three daily injection doses of testosterone propionate (0.125, 0.250, or 0.500 mg/rat) or a control injection of the drug vehicle. Using a plus-maze protocol, we found that a lower testosterone dose (0.125 mg) significantly improved rats’ performance on a response task, whereas a higher testosterone dose (0.500 mg) significantly improved rats’ performance on a place task. In addition, we found that a low dose of testosterone (0.125 mg) increased total BDNF in the striatum, while a high dose (0.500 mg) increased total BDNF in the hippocampus. Taken altogether, these results suggest that high and low levels of testosterone enhance performance on place and response spatial tasks, respectively, and this effect is associated with changes in BDNF levels within relevant brain regions.
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影响因子：
15.9
作者：
Ibáñez, CF
通讯作者：
Ibáñez, CF
影响因子：
2.5
作者：
CLATTERBUCK, RE;PRICE, DL;KOLIATSOS, VE
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KOLIATSOS, VE
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10.6
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Cavus, I;Duman, RS
通讯作者：
Duman, RS
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作者：
Davis, DM;Jacobson, TK;Mizumori, SJY
通讯作者：
Mizumori, SJY
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1.6
作者：
Cherney, Isabelle D.;Brabec, Claire M.;Runco, Daniel V.
通讯作者：
Runco, Daniel V.