Injection drug use and overdose among young adults who use prescription opioids non-medically.
Injection drug use and overdose among young adults who use prescription opioids non-medically.
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DOI：
10.1016/j.addbeh.2017.07.017
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发表时间：
2018-01
影响因子：
4.4
通讯作者：
Marshall BDL
中科院分区：
文献类型：
--
作者：
Liebling EJ;Green TC;Hadland SE;Marshall BDL
在美国，非医用处方阿片类药物(NMPO)的使用是一个严重的公共卫生问题，每年有210万新的印心。年轻的成年NMPO使用者开始注射毒品的风险很高。我们评估了罗德岛年轻成年NMPO使用者注射药物使用的相关性，罗德岛是一个受到阿片类药物过量严重影响的州。我们使用了罗德岛青年成人处方药研究(Rapids)的数据，该研究招募了199名年龄在18-29岁之间的居民，他们报告了超过30天的NMPO使用情况(65.3%是男性)。我们将报告曾经注射过的人与报告从未注射过的人进行比较，使用Logistic回归来确定注射的独立相关因素。在符合条件的参与者中，平均年龄为24.6岁，其中61.3%是白人。超过四分之一(n=59，29.6%)的样本曾经注射过毒品。在注射过毒品的参与者中，大多数(n=46，78.0%)报告说她/他的第一次吸毒是注射海洛因；大多数人还报告说她/他以前吸过第一次注射的毒品(n=46，78.0%)。在多变量分析中，白人种族、年龄较大、终身无家可归、曾过量服药或曾见过过量服药与注射毒品的可能性增加独立相关。这些发现表明，在非医学上使用处方阿片类药物的年轻人中，终身注射毒品的流行率很高。鉴于观察到的注射吸毒与目睹和经历过量之间的联系，迫切需要采取干预措施，以改善对注射毒品的年轻成年非甲氧西林避孕药使用者的过量教育和纳洛酮的分配。
Non-medical prescription opioid (NMPO) use is a critical public health problem in the United States, with 2.1 million new initiates annually. Young adult NMPO users are at high risk for initiating injection drug use. We assessed correlates of injection drug use among young adult NMPO users in Rhode Island, a state heavily impacted by opioid overdose. We used data from the Rhode Island Young Adult Prescription Drug Study (RAPiDS), which recruited 199 residents aged 18–29 who reported past-30-day NMPO use (65.3% male). We compared individuals who reported ever having injected with individuals who reported never injecting, using logistic regression to identify independent correlates of injection. Among eligible participants, the mean age was 24.6 years and 61.3% were white. Over one-quarter (n=59, 29.6%) of the sample had ever injected drugs. The majority (n=46, 78.0%) of participants who had ever injected drugs reported injecting heroin as her/his first drug; the majority also reported previously snorting her/his first drug that was injected (n=46, 78.0%). In multivariable analyses, white race, older age, lifetime homelessness, and ever having overdosed or seen someone overdose were independently associated with an increased likelihood of ever injecting drugs. These findings demonstrate a high prevalence of lifetime injection drug use among young adults who use prescription opioids non-medically. Given the observed associations between injection drug use and witnessing as well as experiencing overdose, interventions are urgently needed to improve overdose education and naloxone distribution to young adult NMPO users who inject drugs.
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影响因子：
0.2
作者：
Dichtl, A.;Stoever, H.;Dettmer, K.
通讯作者：
Dettmer, K.
影响因子：
5.1
作者：
Cerda, Magdalena;Santaella, Julian;Martins, Silvia S.
通讯作者：
Martins, Silvia S.
影响因子：
4.5
作者：
Kerr T;Marshall BD;Miller C;Shannon K;Zhang R;Montaner JS;Wood E
通讯作者：
Wood E
影响因子：
4.2
作者：
Haegerich TM;Paulozzi LJ;Manns BJ;Jones CM
通讯作者：
Jones CM
影响因子：
4.4
作者：
Green, Traci C.;Dauria, Emily F.;Walley, Alexander Y.
通讯作者：
Walley, Alexander Y.