Bioengineering the neurovascular niche to study the interaction of neural stem cells and endothelial cells.
Bioengineering the neurovascular niche to study the interaction of neural stem cells and endothelial cells.
复制标题
DOI：
10.1063/5.0027211
复制
发表时间：
2021-03
影响因子：
6
通讯作者：
Dai G
中科院分区：
文献类型：
--
作者：
Winkelman MA;Koppes AN;Koppes RA;Dai G
哺乳动物神经干细胞（NSCs）在整个成年期自我更新和分化的能力使它们成为研究神经发生和神经退行性疾病治疗的理想选择。在成年哺乳动物大脑中，NSCs维持在神经血管生态位（NVN）中，它们位于特化血管附近，这表明脑内皮细胞（BECs）是NSC命运的重要策划者。然而，目前大多数关于哺乳动物NVN的知识都是从非人类研究中推断出来的。为了规避体内研究的挑战，体外模型已经被开发出来，以更好地了解人类NSCs和BECs的相互细胞机制。这篇综述将涵盖目前对哺乳动物NVN生物学的理解，内皮细胞来源的信号对NSC命运的影响，以及为研究NSCs和BECs之间相互作用而开发的体外模型。
The ability of mammalian neural stem cells (NSCs) to self-renew and differentiate throughout adulthood has made them ideal to study neurogenesis and attractive candidates for neurodegenerative disease therapies. In the adult mammalian brain, NSCs are maintained in the neurovascular niche (NVN) where they are found near the specialized blood vessels, suggesting that brain endothelial cells (BECs) are prominent orchestrators of NSC fate. However, most of the current knowledge of the mammalian NVN has been deduced from nonhuman studies. To circumvent the challenges of in vivo studies, in vitro models have been developed to better understand the reciprocal cellular mechanisms of human NSCs and BECs. This review will cover the current understanding of mammalian NVN biology, the effects of endothelial cell-derived signals on NSC fate, and the in vitro models developed to study the interactions between NSCs and BECs.
登录
查看更多内容
影响因子：
16
作者：
Bersini, Simone;Yazdi, Iman K.;Talo, Giuseppe;Shin, Su Ryon;Moretti, Matteo;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
影响因子：
64.5
作者：
Bonaguidi MA;Wheeler MA;Shapiro JS;Stadel RP;Sun GJ;Ming GL;Song H
通讯作者：
Song H
DOI：
10.1073/pnas.0710000105
发表时间：
2008-01-22
影响因子：
11.1
作者：
Coskun, Volkan;Wu, Hao;Sun, Yi E.
通讯作者：
Sun, Yi E.
影响因子：
2.6
作者：
Acker, T;Beck, H;Plate, KH
通讯作者：
Plate, KH
影响因子：
2.7
作者：
Cheng, AW;Wang, SQ;Mattson, MP
通讯作者：
Mattson, MP