Toll-like receptor 5 gene polymorphism is associated with breast cancer susceptibility.
Toll-like receptor 5 gene polymorphism is associated with breast cancer susceptibility.
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DOI：
10.18632/oncotarget.20242
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发表时间：
2017-10-24
期刊：
影响因子：
--
通讯作者：
Dalin L
中科院分区：
文献类型：
--
作者：
Shuang C;Weiguang Y;Zhenkun F;Yike H;Jiankun Y;Jing X;Xinghan L;Yue L;Dalin L
Toll样受体5（TLR5）在免疫应答中起着重要作用。最近的研究结果表明，TLR5表达水平影响癌症的进展和发展。在本研究中，我们检测了256例乳腺癌标本，发现TLR5在乳腺癌中过表达，并且TLR5过表达与淋巴结转移和癌症分级相关（p<0.01）。在一项病例对照研究中，我们还分析了TLR5单核苷酸多态性（SNP）与乳腺癌风险之间的关联。研究对象为516例汉族女性浸润性导管癌患者和520例年龄匹配的健康对照者。无义SNP rs5744168导致TLR5跨膜信号结构域的截短，并且与乳腺癌风险相关（p<0.05）。然而，SNP rs5744168与任何测试的临床参数之间均未检测到统计学关联。因此，我们的研究结果表明TLR5 SNP rs5744168与散发性乳腺癌的发生相关。
Toll-like receptor 5 (TLR5) plays a fundamental role in immune responses. Recent findings suggest the TLR5 expression level affects cancer progression and development. In the present study, our examination of 256 breast carcinomas specimens revealed that TLR5 is overexpressed in breast carcinomas, and that TLR5 overexpression correlated with lymph node metastasis and cancer grade (p<0.01). In a case-control study, we also analyzed associations between TLR5 single nucleotide polymorphisms (SNPs) and breast cancer risk. Compared were 516 Chinese Han women diagnosed mainly with infiltrative ductal carcinoma and 520 age-matched healthy controls. The nonsense SNP rs5744168 causes truncation of the TLR5 transmembrane signaling domain and was associated with breast cancer risk (p<0.05). However, no statistical association was detected between SNP rs5744168 and any of the clinical parameters tested. Our findings thus indicate that TLR5 SNP rs5744168 is associated with sporadic breast cancer occurrence.
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一种常见的主导TLR5停止密码子多态性废除了鞭毛蛋白信号传导，并与对军团疾病的易感性有关。
影响因子：
15.3
作者：
Hawn, TR;Verbon, A;Lettinga, KD;Zhao, LP;Li, SS;Laws, RJ;Skerrett, SJ;Beutler, B;Schroeder, L;Nachman, A;Ozinsky, A;Smith, KD;Aderem, A
通讯作者：
Aderem, A
影响因子：
3.7
作者：
Hawn TR;Scholes D;Li SS;Wang H;Yang Y;Roberts PL;Stapleton AE;Janer M;Aderem A;Stamm WE;Zhao LP;Hooton TM
通讯作者：
Hooton TM
DOI：
10.1038/nri3921
发表时间：
2015-12
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.8
作者：
Kauppila, J. H.;Mattila, A. E.;Karttunen, T. J.;Salo, T.
通讯作者：
Salo, T.
影响因子：
50.3
作者：
Rutkowski MR;Stephen TL;Svoronos N;Allegrezza MJ;Tesone AJ;Perales-Puchalt A;Brencicova E;Escovar-Fadul X;Nguyen JM;Cadungog MG;Zhang R;Salatino M;Tchou J;Rabinovich GA;Conejo-Garcia JR
通讯作者：
Conejo-Garcia JR